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相关概念视频

Extrinsic and Intrinsic Pathways of Hemostasis01:20

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Blood clotting or coagulation involves extrinsic and intrinsic pathways, which ultimately merge into the common pathway, forming a fibrin clot.
The Extrinsic Pathway
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Hemostasis is a complex physiological process that prevents excessive bleeding when a blood vessel is injured. It's crucial for maintaining the integrity of the circulatory system, as it ensures that our blood remains fluid while still within the vascular network and yet clots to prevent blood loss upon vessel injury.
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相关实验视频

Updated: Jun 19, 2025

Fabrication and Design of Wood-Based High-Performance Composites
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工程高性能复合纤维素材料用于快速静血.

Binshou Wang1,2, Xue Li1, Luyao Wei1,2

  • 1Center of Biomass Engineering/College of Agronomy and Biotechnology, China Agricultural University, Beijing 100193, China.

ACS biomaterials science & engineering
|July 25, 2024
PubMed
概括

开发了一种新的纤维素气凝,用于快速止血,为不受控制的出血提供了具有成本效益和可扩展的解决方案. 这种先进的材料表现出卓越的吸收和血液凝固特性,用于紧急伤口护理.

关键词:
生物质的生物质是生物质.生物材料是一种生物材料.纤维素纤维素的使用方法血静剂是一种血静剂.预处理 预处理

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相关实验视频

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科学领域:

  • 生物材料工程 生物材料工程
  • 材料科学 材料科学 材料科学
  • 医疗器械开发 医疗器械开发

背景情况:

  • 失控出血是创伤伤害后可预防死亡的主要原因.
  • 当前的静血剂往往具有复杂的制备和有限的生物相容性,从而带来挑战.
  • 对于高效,易于制备和生物相容的血静性材料有着至关重要的需求.

研究的目的:

  • 为了设计一种纤维素衍生的气凝,以实现快速的血液静止.
  • 研究冷干燥预处理对气凝特性和静血性能的影响.
  • 阐明结构-功能关系和快速血液静止的机制.

主要方法:

  • 用纤维素再生和受控的干燥过程来制造气凝材料.
  • 评估了四种不同的冷干燥预处理方法.
  • 材料表征包括XRD,FTIR,X射线CT,SEM和泽塔潜力分析.
  • 进行了体外血凝试验,以评估静血疗效.

主要成果:

  • 在没有冷预处理的情况下制备的纤维素气凝表现出最低的结晶度 (21.3%) 和最高的液体吸收率 (其重量的20.3倍).
  • 这种优化的气凝在体外表现出极好的血静,在大约100秒内实现了血液凝结.
  • 添加了凝和二氧化,通过调整功能组和静电性质,进一步提高了静血性能.
  • 鉴定证实了一个超级层次的多孔结构,负责高吸收能力.

结论:

  • 成功开发了一种具有优越的静血能力的成本效益和可扩展的纤维素气凝.
  • 该材料的层次性多孔结构和可调节性质促进了快速的血液静止.
  • 这种气凝代表了一种有前途的候选人,用于在管理严重出血事件的实际应用.