抗高血压药物处方模式和有效性的种族和民族差异
Slavina B Goleva1, Ariel Williams1, David J Schlueter1,2
1National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA.
Clinical pharmacology and therapeutics
|July 25, 2024
概括
与白人相比,黑人和西班牙裔人群的抗高血压药物效果较差. 这表明个性化治疗策略和早期干预措施对于不同的种族和民族群体是必要的.
科学领域:
- 心血管医学 心血管医学
- 药物基因组学 药物基因组学
- 健康差异 在健康上的差异
背景情况:
- 对高血压的处方模式和药物的有效性因种族和族群而异.
- 基本高血压影响着不同的人群,需要了解不同的人群中的治疗疗效.
研究的目的:
- 为了比较自认西班牙裔/拉丁裔,非西班牙裔黑人和非西班牙裔白人参与者的抗高血压药物的有效性和处方模式.
- 为了评估种族和种族差异的反应,通常处方抗高血压药物.
主要方法:
- 一个自我控制的案例研究设计使用了来自17718名参与者在NIH我们所有人研究计划的数据.
- 分析了电子健康记录和调查数据,以比较药物暴露28天以上后的缩血压降低.
- 调整后的线性回归比较了跨种族和种族群体的药物有效性和开始的缩血压.
主要成果:
- 黑人和西班牙裔参与者在大多数药物中,开始时的缩血压高于白人参与者.
- 多种抗高血压药物更频繁地被处方给黑人参与者 (58.46%).
- 大多数抗高血压药物在黑人和西班牙裔人群中表现出相比于白人个体的有效性降低,在19种药物中的6种药物中具有统计学意义.
结论:
- 在抗高血压药物的有效性和处方方面存在种族和民族差异.
- 黑人和西班牙裔人口可能需要更早的查和个性化的第一线药物治疗策略.
- 根据种族和种族来定制高血压治疗可能会改善患者的治疗结果.
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