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放射性诊断中的化对比介质诱导的过敏反应:基于FAERS数据库的不成比例分析
Jinjin Long1, Yifan Yi1, Yawen Zhang1
1Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, China.
Current medical imaging
|July 25, 2024
概括
药监数据显示,对于非离子有氧对比剂 (ICM) 的过敏反应存在不同的风险. 伊奥赫索尔, 艾奥维索尔, 艾奥普罗米德, 艾奥梅普罗尔, 艾奥比特里多尔和 艾奥迪克萨诺尔的风险比艾奥帕米多尔更高.
科学领域:
- 放射学 放射学是一门学科.
- 药物监督 药物监督 药物监督
- 医疗成像医学成像
背景情况:
- 对含对比剂 (ICM) 的过敏反应是放射学中的一个问题.
- 了解不同非离子ICM的药物监测 (PV) 和严重性概况对于患者的安全至关重要.
研究的目的:
- 评估非离子ICM诱导的过敏反应的药物监测和严重程度.
- 基于FAERS数据,比较常用的非离子ICM的风险概况.
主要方法:
- 在FAERS数据库中对ICM诱导过敏反应报告的回顾性分析 (2015年1月至2023年1月).
- 对七种非离子ICM的不成比例性分析:IOHEXOL,IOPAMIDOL,IOVERSOL,IOPROMIDE,IOMEPROL,IOBITRIDOL和IODIXANOL.这些物质中含有多种离子物质.
- 使用STATA 17.0 MP. 的统计分析.
主要成果:
- 在35357个不良事件中,共发现了6181个过敏反应报告.
- 对于IOHEXOL,IOVERSOL,IOPROMIDE,IOMEPROL,IOBITRIDOL和IODIXANOL检测到过敏反应的PV信号,但并没有检测到IOPAMIDOL.
- 约美醇显示过敏反应的比例增加,而约美醇和约维醇显示严重反应的可能性显著增加.
结论:
- 非离子ICM表现出不同的过敏反应的概率和严重程度.
- 与约帕米多尔相比,Iohexol,ioversol,iopromide,iomeprol,iobitridol和iodixanol具有更高的风险.与此相比,iopamidol的风险更高.
- 特定的ICM如iomeprol和ioversol需要仔细考虑,因为过敏反应的发生率和严重程度增加.
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