与皮质厚度变化相关的基因在行为成中发生变化
Hongsheng Xie1,2, Yuanyuan Wang3, Fei Zhu3
1Department of Nuclear Medicine, West China Hospital of Sichuan University, No. 37 Guo Xue Alley, 610041, Chengdu, Sichuan, China.
Cerebral cortex (New York, N.Y. : 1991)
|July 25, 2024
概括
行为成与对认知控制至关重要的大脑区域的皮质厚度较薄有关. 这种大脑结构差异可能与特定的基因表达有关,包括多巴胺D2受体.
科学领域:
- 神经科学是一个神经科学.
- 遗传学 是一个遗传学.
- 精神病学是一个精神病学.
背景情况:
- 行为成 (BA) 是一个日益关注的问题,其特点是强迫性行为尽管负面的结果.
- BA的神经遗传基础在很大程度上仍未确定.
- 了解这些机制对于开发有效的干预措施至关重要.
研究的目的:
- 为了研究皮质厚度 (CTh) 和行为上个体的遗传因素之间的关系.
- 确定受BA中CTh变化影响的特定大脑区域.
- 探索观察到的CTh变化的遗传相关性.
主要方法:
- 在五个数据库中进行系统的文献搜索.
- 对10项比较BA患者和对照组中CTh的研究的元分析.
- 超回归来评估CTh与成严重程度的关联.
- 来自艾伦人类大脑图谱的CTh表型和基因表达数据之间的相关性分析.
- 基因丰富分析以确定生物途径.
主要成果:
- 与对照人群相比,BA患者在前皮质,后中心,轨道前皮质和背侧前额皮质中表现出明显较薄的CTh (P < 0.005).
- 在前结和后中心结中降低的CTh与成严重程度负相关 (P < 0.0005).
- 在BA的CTh变化与12个基因的表达空间相关 (FDR <0.05),特别是多巴胺D2受体 (rho = 0.55).
- 丰富的生物过程包括行为调节和对刺激的反应 (FDR < 0.05).
结论:
- 这项研究表明,在行为上的个体中,关键的认知控制区域的皮质厚度减少.
- 这些CTh变化可能与参与多巴胺代谢和行为调节的基因表达有关.
- 这些发现为潜在的行为成的神经遗传机制提供了新的见解.
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