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相关概念视频

Structure of a Gene01:30

Structure of a Gene

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A gene is the fundamental unit of heredity. Every individual has two copies of each gene, one inherited from each parent. Although most people contain the same genes, there is a small fraction that is slightly different amongst people. A gene with a small difference in its sequence of DNA bases forms different alleles, contributing to different phenotypes.
However, only 1% of the DNA is composed of genes that encode proteins; the rest, 99% is non-coding DNA. This non-coding DNA performs...
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What is Gene Expression?01:42

What is Gene Expression?

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Overview
Gene expression is the process in which DNA directs the synthesis of functional products, that is, proteins. Cells can regulate gene expression at various stages. It allows organisms to generate different cell types and enables cells to adapt to internal and external factors.
Genetic Information Flows from DNA to RNA to Protein
A gene is a stretch of DNA that serves as the blueprint for functional RNAs and proteins. Since DNA is made up of nucleotides and proteins consist of amino...
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Regulation of Expression at Multiple Steps01:23

Regulation of Expression at Multiple Steps

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The gene expression in cells is regulated at different stages: (i) transcription, (ii) RNA processing, (iii) RNA localization, and (iv) translation. Transcriptional regulation is mediated by regulatory proteins such as transcription factors, activators, or repressors—these control gene expression by initiating or inhibiting the transcription of genes. Once a precursor or pre-mRNA is produced, it undergoes post-transcriptional modification, including 5' capping, splicing, and the...
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Regulation of Expression Occurs at Multiple Steps02:24

Regulation of Expression Occurs at Multiple Steps

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Gene expression can be regulated at almost every step from gene to protein. Transcription is the step that is most commonly regulated. This involves the binding of proteins to short regulatory sequences on the DNA. This association can either promote or inhibit the transcription of a gene associated with the respective sequence.
Transcription results in the generation of precursor (pre-mRNA) that consists of both exons and introns, which needs further processing before being translated to a...
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Protein Networks02:26

Protein Networks

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An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
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Cell Specific Gene Expression01:58

Cell Specific Gene Expression

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Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same parent cells. The differences in the cells can be attributed to the differential gene expression. Liver cells, whose functions include detoxification of blood, production of bile to metabolize fats, and synthesis of proteins essential for metabolism, must express a specific set of genes to perform their functions. Gene expression also varies with...
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相关实验视频

Updated: Jun 19, 2025

Author Spotlight: Impact of Intergenic Interactions on Disease-Identifying Dark Biomarkers
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Author Spotlight: Impact of Intergenic Interactions on Disease-Identifying Dark Biomarkers

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使用贝叶斯网络中隐含的潜在结构来表示核心基因表达活动关系.

Jiahao Gao1, Mark Gerstein1,2,3,4

  • 1Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT 06520, United States.

Bioinformatics (Oxford, England)
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概括
此摘要是机器生成的。

我们开发了LatentDAG,这是一个简化基因表达关系的贝叶斯网络. 这种网络比传统的基因网络提供了更清晰的生物学见解,改善了基因保护预测等任务.

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Inherent Dynamics Visualizer, an Interactive Application for Evaluating and Visualizing Outputs from a Gene Regulatory Network Inference Pipeline
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Mapping Bacterial Functional Networks and Pathways in Escherichia Coli using Synthetic Genetic Arrays
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Mapping Bacterial Functional Networks and Pathways in Escherichia Coli using Synthetic Genetic Arrays

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相关实验视频

Last Updated: Jun 19, 2025

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Published on: March 1, 2024

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Inherent Dynamics Visualizer, an Interactive Application for Evaluating and Visualizing Outputs from a Gene Regulatory Network Inference Pipeline
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科学领域:

  • 生物信息学是一种生物信息学.
  • 系统生物学 系统生物学
  • 计算生物学 计算生物学

背景情况:

  • 基因调控网络 (GRNs) 和共同表达网络在生物医学研究中至关重要.
  • 这些网络往往过于复杂,类似于'毛球',阻碍了解释和生物洞察力.

研究的目的:

  • 开发一个简化的网络模型来总结核心基因表达关系.
  • 提高生物网络的可解释性,用于生物医学研究.

主要方法:

  • 提出了贝叶斯网络方法,称为LatentDAG,用于建模基因表达活动.
  • 将LatentDAG的性能与传统的共同表达和ChIP-seq网络进行了比较.
  • 集成的LatentDAG与图形神经网络,用于下游生物任务.

主要成果:

  • 与现有的方法相比,LatentDAG显著降低了网络复杂性 (大小的两个数量级).
  • 潜伏DAG模型揭示了更清晰的基因和模块分离.
  • 证明了LatentDAG与其他生物网络 (例如,RNA结合蛋白相互作用) 架起桥梁的能力.
  • 当与图形神经网络相结合时,LatentDAG在预测基因保存和基因聚类方面表现优于其他网络.

结论:

  • LatentDAG提供了一个更简单,更易于解释的基因表达关系的表现.
  • 这种新的网络方法增强了生物网络对各种计算生物学任务的实用性.
  • 潜伏DAG框架为剖析复杂的基因调节机制提供了一个强大的工具.