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Updated: Jun 19, 2025

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
10:33

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors

Published on: October 26, 2015

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迪纳西克利布的CDK9抑制是表皮质血管内皮质瘤的治疗脆弱性

Ajaybabu V Pobbati1,2, Ashley Burtscher1, Nandini Rajaram Siva1

  • 1Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio.

Clinical cancer research : an official journal of the American Association for Cancer Research
|July 25, 2024
PubMed
概括

像dinaciclib (Dina) 这样的循环素依赖激酶 (CDK) 抑制剂,可以调动TAZ-CAMTA1 (TC) 融合蛋白,从而导致其降解. 这种方法对通过减少瘤生长和转移来治疗侵袭性表皮性血管内皮瘤 (EHE) 有希望.

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A Murine Cell Line Based Model of Chronic CDK9 Inhibition to Study Widespread Non-Genetic Transcriptional Elongation Defects TEdeff in Cancers10:49

A Murine Cell Line Based Model of Chronic CDK9 Inhibition to Study Widespread Non-Genetic Transcriptional Elongation Defects TEdeff in Cancers

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