老年人早期发作和晚期发作焦点的结构和功能异常以及认知特征
Xinyue Wan1,2, Yanwei Zeng1, Jianhong Wang3
1Department of Radiology, Huashan Hospital, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai 200040, China.
Cerebral cortex (New York, N.Y. : 1991)
|July 25, 2024
概括
早期发作和晚期发作的焦点显示出明显的结构和功能性大脑变化,影响认知能力. 这些结构功能性改变可能有助于诊断焦点.
科学领域:
- 神经成像是一种神经成像.
- 的研究研究.
- 认知神经科学 认知神经科学
背景情况:
- 焦点 (OFE) 根据发病年龄呈现不同,影响结构,功能和认知.
- 了解这些与年龄相关的差异对于准确的诊断和管理至关重要.
研究的目的:
- 研究早期发作与晚期发作焦点中大脑结构,功能和认知表现的年龄相关差异.
- 探索神经成像发现和认知评估之间的关系.
- 为了确定结构功能合在的诊断潜力.
主要方法:
- 基于变形的形态测量用于结构异常的检测.
- 基于种子的功能连接性分析.
- 图像和神经精神病学评估之间的相关性分析.
- 调解分析以探索诊断角色.
主要成果:
- 早期发病的OFE显示小脑,乳头,环状皮质和叶片的结构体积减少.
- 晚期发病的OFE患者表现出小脑,乳头和环膜缩.
- 与认知评估缺陷相关的结构异常.
- 大脑,带状和额头状圈连接问题部分介导着早期发病的OFE诊断.
结论:
- 显著的结构和功能性脑部异常是早期发作和晚期发作的焦点的特征.
- 认知表现与这些神经成像改变有关.
- 结构功能合显示为的诊断生物标志物具有前途.
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