淋巴瘤和慢性淋巴细胞白血病患者疫苗反应的免疫学预测因素
Elise A Chong1,2, Kingsley Gideon Kumashie3, Emeline R Chong1
1The Richard Berman Family Innovations Center in CLL and Lymphomas, Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania.
The Journal of infectious diseases
|July 25, 2024
概括
淋巴瘤患者的疫苗反应因治疗阶段而异. 针对COVID-19疫苗接种的最佳时间需要进一步研究,以改善免疫健康并个性化癌症治疗计划.
科学领域:
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
- 疫苗学 疫苗学 疫苗学
背景情况:
- B细胞淋巴瘤及其治疗显著损害了接种疫苗的反应.
- 与癌症治疗相比,接种疫苗的理想时间尚未确定.
- 严重急性呼吸系统综合征冠状病毒2 (SARS-CoV-2) 疫苗为癌症患者的疫苗时间研究提供了一种新型抗原.
研究的目的:
- 调查淋巴瘤和慢性淋巴细胞白血病 (CLL) 患者的血清信息 RNA (mRNA) 疫苗反应.
- 在不同治疗阶段识别影响疫苗反应时间的因素.
- 探索免疫细胞种群与疫苗反应性之间的关系.
主要方法:
- 回顾性和前性队列研究设计.
- 对血清学疫苗反应的分析,以及临床和研究免疫参数.
- 免疫球蛋白A (IgA) 和免疫球蛋白M (IgM) 水平的评估.
- 用抗CD19仿真抗原受体 (CAR) T细胞治疗的患者的B和T毛囊辅助细胞计数的评估.
主要成果:
- 在活跃的癌症治疗期间,血清学疫苗反应的减少更为频繁.
- 在观察组和治疗后组中也观察到没有对疫苗的反应.
- 较高的总IgA和IgM水平与成功的疫苗反应相关.
- 对抗CD19的CAR T细胞治疗患者的无反应与较低的B和T毛囊辅助细胞数量有关.
结论:
- 根据淋巴瘤亚型和治疗干预措施,疫苗反应预测因素有所不同.
- 免疫细胞概况,特别是B和T毛囊辅助细胞,与特定疗法后的疫苗反应有关.
- 进一步的研究对于优化免疫功能低下的癌症患者的疫苗时间和改善治疗期间和治疗后的免疫健康至关重要.
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