低剂量 ортотоп癌植入允许测量与缓解症相关的纵向功能变化
Ishan Roy1,2,3, Benjamin Binder-Markey4, Amber Willbanks1
1Shirley Ryan AbilityLab, Chicago, Illinois, United States.
Journal of applied physiology (Bethesda, Md. : 1985)
|July 25, 2024
概括
与癌症相关的缓解症会导致逐渐的功能衰退. 这项研究发现,步行速度,而不是握力,在新的延长生存癌症模型中准确地测量了身体功能下降.
科学领域:
- 在瘤学瘤学.
- 身体生理学 身体生理学
- 动物模型 动物模型
背景情况:
- 癌症相关的缓解症的特点是功能逐渐下降,阻碍了临床前治疗转化.
- 现有的癌症模型通常具有很短的生存时间,并使用非特定的身体功能指标,如握力.
- 开发具有延长生存期和准确功能评估的模型对于缓解症研究至关重要.
研究的目的:
- 为了延长K-ras; Trp53; Pdx-1-Cre (KPC) 癌症模型的存活时间.
- 用一系列的评估技术来调查与缓解症相关的功能衰退.
- 为了确定可靠的替代措施,在癌症缓解症的身体功能.
主要方法:
- 使用低剂量 (100细胞) DT10022 KPC细胞的KPC基因组模型的生存延长.
- 用解剖学,生物化学和行为技术评估128只动物的评估,以评估缓解症表型.
- 对步行速度和握力下降的分析与缓解症进展的关系.
主要成果:
- 植入后KPC正型模型的存活时间延长到8-9周.
- 在低剂量 ортотоп (LO) 模型中检测到渐进的肌肉衰竭和全身炎症.
- 步行速度下降被确定为缓解症相关功能下降的早期和特定指标,与握力不同.
结论:
- 步行速度是比握力更准确的替代品来评估与缓解症相关的身体功能.
- 开发的具有延长生存期的低剂量正位体 (LO) 模型有助于详细调查缓解症.
- 需要进一步的研究,以阐明这些功能性变化在缓冲症的生理基础.
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