空气中的颗粒物 (PM2.5) 暴露水平与初级开角绿内障之间的关联
Yi Ma1, Mingxi Shao2, Shengjie Li1
1Department of Clinical Laboratory, Eye & ENT Hospital, Fudan University, Shanghai 200031, China; Department of Ophthalmology & Visual Science, Eye & ENT Hospital, Shanghai Medical College, Fudan University, Shanghai 200031, China.
Ecotoxicology and environmental safety
|July 25, 2024
概括
暴露于细颗粒物 (PM2.5) 空气污染与增加眼内压力和降低视觉敏感性有关. 较长的暴露时间,特别是三个月,与疾病严重程度的增加相关.
科学领域:
- 眼科医生 眼科 眼科
- 环境健康 环境健康
- 公共卫生 公共卫生
背景情况:
- 人们认识到眼睛对空气污染的脆弱性,细颗粒物 (PM2.5) 已被证明对眼睛组织有毒作用.
- 临床证据将空气污染物暴露与绿眼的功能和结构变化联系在一起是有限的.
- 玻璃眼,特别是初级开角玻璃眼 (POAG),影响全球数百万,需要对环境风险因素进行研究.
研究的目的:
- 调查空气污染暴露,特别是PM2.5和初级开角绿内障 (POAG) 患者的眼睛参数之间的关联.
- 探索不同暴露时间 (每天,一个月,三个月) 的PM2.5对眼内压力 (IOP) 和视野平均灵敏度 (MS) 的影响.
- 为了确定PM2.5暴露是否是POAG严重程度的独立风险因素.
主要方法:
- 一项涉及上海120名POAG患者的回顾性研究.
- 标准化眼科检查包括IOP,视野和光学连贯性断层扫描.
- 收集每日,一个月和三个月平均PM2.5度和空气质量指数 (AQI) 数据.
主要成果:
- 一个月和三个月的平均PM2.5暴露水平较高与增加的IOP和视野平均灵敏度 (MS) 的降低有关.
- 每日PM2.5度与眼睛参数没有显著的关联.
- 三个月的PM2.5平均暴露被确定为POAG严重程度的独立风险因素.
结论:
- 这项研究为PM2.5空气污染暴露与POAG患者的眼部不良结果之间的联系提供了临床证据.
- 一个月的PM2.5暴露显著影响了IOP,而三个月的暴露与POAG严重程度有关.
- 研究结果表明,减少对PM2.5的暴露可能有利于治疗眼.
相关概念视频
Open Angle Glaucoma: Treatment
422
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Drugs such as carbonic anhydrase inhibitors, α2- and...
422
Glaucoma: Overview
534
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
534
Angle Closure Glaucoma: Treatment
468
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
468
Photoreceptors and Visual Pathways
6.0K
At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category,...
6.0K


