在循环压力负荷下,阿基里斯肌凝结的行为:卸载和早期重新动员的后果
Claire Camy1, Aurélien Maurel-Pantel2, Marylène Lallemand3
1Aix Marseille Univ, CNRS, ISM, 13009 Marseille, France; Aix Marseille Univ, APHM, CNRS, ISM, Mecabio Platform, Department of Orthopaedics and Traumatology, 13009 Marseille, France.
Journal of biomechanics
|July 25, 2024
概括
后肢的卸载会损害阿基里斯内 (ATE) 的机械功能,降低其承受压力的能力. 重装部分恢复功能,但改变了刚性和粘度,强调在运动期间需要仔细管理负载.
科学领域:
- 生物医学工程 生物医学工程
- 肌肉骨生物学 肌肉骨生物学
- 组织力学 组织力学
背景情况:
- 阿基里斯肌内 (ATE) 对于负载传输至关重要,由富含II型原蛋白和蛋白质甘氨酸 (PGs) 的纤维软骨组成.
- 机械负荷会影响ATE的改造,这表明慢性负荷变化可以在压力压力下改变其机械性能.
研究的目的:
- 为了研究后肢卸载和随后的重新加载对老鼠在循环压缩负荷下阿基里斯肌结合的疲劳行为的影响.
- 质量评估ATE纤维软骨中蛋白质甘油的变化.
主要方法:
- 循环压缩负荷被应用到小鼠ATE后14天的后肢悬浮和6天的重新加载.
- 测量了机械参数,包括位移,hysteresis面积和刚度.
- 对ATE纤维软骨中的蛋白质甘油进行了组织学分析.
主要成果:
- 卸载显著损害了ATE的机械行为,排位损失27%,歇斯底里斯面积减少27%,硬度增加45%.
- 与对照组相比,重新加载导致歇斯底里面积减少了28%,硬度增加了26%.
- 这些机械变化与未化ATE中的蛋白质甘氨酸的变化相关.
结论:
- 慢性卸载和随后的重新加载显著改变了阿基里斯肌内的机械特性.
- 在ATE中的蛋白质甘油含量似乎在负载依赖的机械反应中起作用.
- 管理压力负荷对于涉及ATE的预防和康复练习至关重要.
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