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具有不同功能组的微塑料在绿色微藻Scenedesmus obliquus上调节了减少氧化石墨烯毒性的细胞和分子机制

Xibo Lu¹, Qi Yu², Seyed Ali Johari³

¹School of Environmental Science and Engineering, Collaborative Innovation Center of Atmospheric Environment and Equipment Technology, Jiangsu Key Laboratory of Atmospheric Environment Monitoring and Pollution Control, Nanjing University of Information Science and Technology, Nanjing, 210044, PR China.

Plant physiology and biochemistry : PPB

|July 25, 2024

概括

微塑料 (MP) 和减少氧化石墨烯 (RGO) 对藻类的联合毒性取决于MP的功能组. 氨基基修饰的MP减轻了RGO毒性,而碳氧基修饰的MP加剧了RGO毒性,揭示了复杂的纳米材料相互作用.

科学领域:

环境毒理学环境毒理学
纳米科学是一个纳米科学.
水生生态学水生生态学

背景情况:

微塑料 (MP) 和石墨烯纳米材料 (GNM) 对水生生物具有个别毒性.
对于MP和GNM的联合毒性和潜在机制的了解有限.
具有不同功能组 (未经修改,COOH-,NH2-) 和减少氧化石墨烯 (RGO) 的聚烯MP是关键的环境污染物.

研究的目的:

调查功能化MP和RGO对淡水藻类*Scenedesmus obliquus*的单独和联合毒性.
阐明观察到的联合毒性背后的细胞和分子机制.
评估MP功能组对RGO诱导的毒性和压力反应的影响.

主要方法:

暴露 *S. obliquus* 不同度的未经修改,COOH-修改和NH2-修改的MPs,单独和与RGO结合.
增长抑制,细胞膜完整性和氧化应激生物标志物的评估.
氧化应激和光合作用相关基因表达的分析.

主要成果:

单独和与MPs结合,RGO表现出度依赖的生长抑制.
修改为NH2的MP显著减轻了RGO毒性,而COOH修改的MP则加剧了RGO毒性.
国会议员影响了RGO对细胞膜完整性和氧化应激生物标志物的影响,但对基因表达没有显著的影响.

结论:

微塑料上的功能组批判性地调节了MP和RGO的联合毒性.
氨基功能化MP可以减轻RGO诱导的毒性,提供潜在的缓解见解.
综合暴露风险是复杂的,取决于材料特性,需要进一步的机制研究.

关键词:

基因毒性基因毒性微塑料是一种微塑料.混合物的毒性混合物的毒性纳米毒性纳米毒性氧化应激是一种氧化应激.

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