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使用PEGylatedβ-cyclodextrin-curcumin功能化的纳米复合物,针对pH量身定制的多目标抗癌胺衍生物的输送

Heba Shawky¹, Dalia B Fayed¹, Noha E Ibrahim²

¹Therapeutic Chemistry Department, Pharmaceutical Industries and Drug Research Institute, National Research Centre, Dokki, 12622 Cairo, Egypt.

Biomaterials advances

|July 25, 2024

概括

这项研究开发了一种新型的胺载纳米复合物 (BMPE-Cur) 来改善抗癌药物输送. 该配方显示增强抗癌活性和对癌细胞的选择性,提供了一个有前途的治疗策略.

科学领域:

纳米技术纳米技术
材料科学材料科学材料科学
药理学药理学是指药理学的学科.

背景情况:

西米达衍生物显示出抗癌潜力,但其生物可用性较差.
开发有效的药物输送系统对于提高治疗疗效至关重要.

研究的目的:

为了创建一个新的纳米基药物输送系统,用于本齐米达衍生物.
为了提高本齐米达化合物的生物可用性和抗癌活性.
评估开发的纳米复合体的物理化学特性和生物活动.

主要方法:

准备和表征的西米达装载的聚乙烯糖醇-β-环氧化-功能化黄素纳米复合物 (BMPE-Cur).
在不同的pH条件下评估物理化学性质 (颗粒大小,泽塔潜力) 和药物释放概况.
在体外评估抗氧化剂和亲细胞生成活性对各种癌细胞系 (HepG2,PC3,MCF-7-ADR) 和正常细胞系 (Wi-38).

主要成果:

一个稳定的聚合物纳米复合物 (BMPE-Cur) 平均粒子大小为467.7nm和负泽塔电位 (-28.24mV) 已成功合成.
该纳米复合体表现出pH敏感的持续药物释放,模仿瘤微环境条件.
BMPE-Cur证明了显著的激素清除能力,并诱导了DNA碎片化驱动的癌细胞细胞循环停止,具有显著的选择性.

结论:

开发的BMPE-Cur纳米复合物有效地提高了本齐米达衍生物的生物可用性和抗癌潜力.
该配方表现出强烈的抗氧化剂和选择性亲吸收性质,使其成为一个有前途的多目标抗癌剂.
这种以纳米为基础的方法提供了一种可行的策略,用于改善基于本齐米达的抗癌药物的治疗结果.

关键词:

西米达 (Benzimidazole) 是一种一种库尔库明是一种黄素.药物输送是药物输送的过程.多重目标的抗癌药物聚合物纳米复杂物这是β-Cyclodextrin.

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