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氨酸提高了衰老败血症的生存率,调节了肠道微生物组,并预防了败血症相关的脑病变
Kejia Xu1, Qiong Huang2, Ying Lyu3
1Department of Anesthesiology and Hongqiao International Institute of Medicine, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200336, China.
概括
脂素 (PS) 改善了患有败血症的小鼠的生存率,并减少了神经炎症. 这项研究表明,PS可能是治疗败血症相关脑病变和老年人认知能力下降的有希望的治疗方法.
科学领域:
- 生物医学科学 生物医学科学
- 神经科学是一个神经科学.
- 微生物学 微生物学
背景情况:
- 败血症会导致严重的并发症,特别是在老年人中,由于治疗不有效.
- 氨酸氨酸 (PS),一种营养补充剂,以其认知益处而闻名,但其在败血症中的作用尚未得到充分探索.
- 败血症相关脑病变 (SAE) 在患者的康复和长期健康方面存在重大挑战.
研究的目的:
- 调查脂素 (PS) 在改善败血症和败血症相关脑病变 (SAE) 的结果方面的疗效.
- 评估PS对生存率,神经行为障碍和毒症模型中潜在的分子机制的影响.
主要方法:
- 中年老鼠在通过脂多糖诱导败血症之前被用PS治疗了两个月.
- 败血症后,评估了生存率,随后对幸存的小鼠进行了神经行为测试 (开放场地,穿箱).
- 分析了卡斯帕斯-3,质标记物,海马细胞因子基因表达 (TBK1/NLRP3/ASC通路),肠道微生物群多样性 (β-多样性),状体形态和结肠ZO-1表达.
主要成果:
- 施用PS显著增加了败血症后小鼠的存活率.
- 幸存的小鼠在PS预治疗后显示神经行为障碍的潜在缓解.
- 在海马体中,PS降低了神经元分裂-caspase3,质标记物和促炎性细胞因子基因表达.
- PS调节了肠道微生物的β-多样性,保留了阴茎形态,并保持了结肠ZO-1表达.
结论:
- 酸丁 (PS) 显示出提高败血症生存率的潜力.
- 治疗PS可能会改善神经行为缺陷,并减少与败血症和SAE相关的脑病理.
- PS调节肠道微生物组并保持肠道完整性,有助于整体改善结果.
- 这些发现突出了PS作为毒症的潜在治疗剂,以及在老年人群中保持认知功能.
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