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水管烟草吸烟和多发性硬化症:系统性审查和元分析

Elham Bazmi^1,2, Amir Hossein Behnoush³, Moahmmad Taghi Talebian⁴

¹Neurology Department, Multiple Sclerosis Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Sina Hospital, Tehran, Iran.

Neuroepidemiology

|July 25, 2024

概括

水管吸烟与患多发性硬化症 (MS) 的风险增加有关. 即使是过去的水管使用也显示出强烈的相关性,突出显示了MS患者潜在的公共卫生问题.

科学领域:

神经学神经学
公共卫生公共卫生
流行病学流行病学

背景情况:

多发性硬化症 (MS) 是中枢神经系统的衰弱性自身免疫性疾病,对全球健康产生影响.
烟草吸烟是一种常见的习惯,在全球范围内,烟草吸烟的流行度正在上升.
了解水管使用与MS之间的联系对于公共卫生倡议至关重要.

研究的目的:

系统地评估烟斗吸烟与患多发性硬化症 (MS) 的风险之间的关联.
通过元分析综合现有证据,量化水管使用与MS之间的关系.
为临床实践提供有关患者风险分层和护理的信息.

主要方法:

在主要的数据库中进行了系统的文献搜索:PubMed,Scopus,Web of Science和Embase.
研究经过严格选,按标题/摘要,然后进行全文审查,以确保相关性.
从包含的研究中提取了数据,并使用几率比率 (OR) 和95%置信区间 (CI) 进行了随机效应元分析.

主要成果:

五项涉及3087名个人 (1135名MS患者) 的研究被纳入了元分析.
经常吸烟的水管显示出与MS的显著关联 (OR: 1.73,95% CI: 1.38-2.17).
过去的水管吸烟也显示出与MS的显著关联 (OR: 2.17,95% CI: 1.61-2.92),与烟草吸烟相结合时具有添加效应. 没有发现与疾病严重程度 (EDSS) 的联系.

结论:

水管吸烟与多发性硬化症的风险增加有显著的关联.
即使是间歇性或过去的水管使用也与MS诊断的可能性更高有关.
需要进一步的大规模研究来证实这些发现,并指导对MS患者的临床风险评估.

关键词:

进行元分析分析.多发性硬化症是多发性硬化症.系统性审查系统性审查烟草烟草烟草烟草烟草水管是水管中的一部分.

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