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相关概念视频

Typical Model Studies01:30

Typical Model Studies

354
Fluid mechanics model studies often utilize scaled-down systems to predict fluid behavior in full-scale environments, such as river flows, dam spillways, and structures interacting with open surfaces. Maintaining Froude number similarity in river models is crucial, as it replicates surface flow features like wave patterns and velocities.
354
Design Example: Creating a Hydraulic Model of a Dam Spillway01:21

Design Example: Creating a Hydraulic Model of a Dam Spillway

157
Scaled hydraulic models of dam spillways provide a practical way to replicate and study the intricate flow dynamics of these structures. Often built to a 1:15 ratio, these models allow for observing critical water behavior, such as velocity distribution, flow patterns, and energy dissipation.
157
One-Compartment Open Model: Wagner-Nelson and Loo Riegelman Method for ka Estimation01:24

One-Compartment Open Model: Wagner-Nelson and Loo Riegelman Method for ka Estimation

449
This lesson introduces two critical methods in pharmacokinetics, the Wagner-Nelson and Loo-Riegelman methods, used for estimating the absorption rate constant (ka) for drugs administered via non-intravenous routes. The Wagner-Nelson method relates ka to the plasma concentration derived from the slope of a semilog percent unabsorbed time plot. However, it is limited to drugs with one-compartment kinetics and can be impacted by factors like gastrointestinal motility or enzymatic degradation.
On...
449
Solution Equilibrium and Saturation01:59

Solution Equilibrium and Saturation

18.5K
Imagine adding a small amount of sugar to a glass of water, stirring until all the sugar has dissolved, and then adding a bit more. You can repeat this process until the sugar concentration of the solution reaches its natural limit, a limit determined primarily by the relative strengths of the solute-solute, solute-solvent, and solvent-solvent attractive forces. You can be certain that you have reached this limit because, no matter how long you stir the solution, undissolved sugar remains. The...
18.5K
The Integrated Rate Law: The Dependence of Concentration on Time02:39

The Integrated Rate Law: The Dependence of Concentration on Time

34.9K
While the differential rate law relates the rate and concentrations of reactants, a second form of rate law called the integrated rate law relates concentrations of reactants and time. Integrated rate laws can be used to determine the amount of reactant or product present after a period of time or to estimate the time required for a reaction to proceed to a certain extent. For example, an integrated rate law helps determine the length of time a radioactive material must be stored for its...
34.9K
Modeling and Similitude01:12

Modeling and Similitude

261
Scaled modeling is a fundamental technique in engineering, enabling the study of large and complex systems by creating smaller, manageable replicas that recreate critical characteristics of the original. In hydrology and civil infrastructure, for example, scaled models of dams help analyze water flow, turbulence, and pressure. This method allows for accurate predictions of real-world behavior within a controlled environment, significantly reducing the cost and time involved in full-scale...
261

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相关实验视频

Updated: Jun 19, 2025

Dynamic Pore-scale Reservoir-condition Imaging of Reaction in Carbonates Using Synchrotron Fast Tomography
10:18

Dynamic Pore-scale Reservoir-condition Imaging of Reaction in Carbonates Using Synchrotron Fast Tomography

Published on: February 21, 2017

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基于动态溶解率测试的新数学模型.

A Ruiz-Picazo1, I Gonzalez-Alvarez1, M Bermejo1

  • 1Department Engineering Pharmacy Section, Miguel Hernandez University, San Juan de Alicante 03550 Alicante, Spain.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
|July 25, 2024
PubMed
概括
此摘要是机器生成的。

一个新的数学模型准确地描述了药物的溶解和沉,有助于开发更好的低溶性药物的体外溶解试验 (BCS Class 2). 这种实用方法有助于优化制药配方.

关键词:
双重的威布尔是双重的威布尔.优秀的解决方案解决方案.数学建模的数学建模降水量 降水量 降水量超和 超和 超和两个阶段的溶解.

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The Use of Chemostats in Microbial Systems Biology
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The Use of Chemostats in Microbial Systems Biology

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Dissolution Dynamic Nuclear Polarization Instrumentation for Real-time Enzymatic Reaction Rate Measurements by NMR
10:54

Dissolution Dynamic Nuclear Polarization Instrumentation for Real-time Enzymatic Reaction Rate Measurements by NMR

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相关实验视频

Last Updated: Jun 19, 2025

Dynamic Pore-scale Reservoir-condition Imaging of Reaction in Carbonates Using Synchrotron Fast Tomography
10:18

Dynamic Pore-scale Reservoir-condition Imaging of Reaction in Carbonates Using Synchrotron Fast Tomography

Published on: February 21, 2017

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The Use of Chemostats in Microbial Systems Biology
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The Use of Chemostats in Microbial Systems Biology

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Dissolution Dynamic Nuclear Polarization Instrumentation for Real-time Enzymatic Reaction Rate Measurements by NMR
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Dissolution Dynamic Nuclear Polarization Instrumentation for Real-time Enzymatic Reaction Rate Measurements by NMR

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科学领域:

  • 制药科学 制药科学
  • 物理化学 物理化学
  • 数学建模的数学建模

背景情况:

  • 在体外溶解测试对于预测药物性能至关重要,但目前的方法与低可溶性药物的复杂行为作斗争.
  • 生物制药分类系统 (BCS) 的2a,2b和2c子类中的药物具有pH依赖的溶解性,使溶解概况复杂化.
  • 在体外复制体内条件需要先进的方法来捕捉溶解和沉动力学.

研究的目的:

  • 开发和验证一种用于分析复杂溶解和沉现象的新型数学模型.
  • 评估模型在适应BCS类2药物的实验数据方面的准确性.
  • 为制药研究人员提供一种实际的工具,以了解药物行为.

主要方法:

  • 修改后的双维布尔方程被用于模拟溶解和沉动力学.
  • 该模型应用于两阶段和转移溶解实验 (倾销试验).
  • 来自BCS类2a和2b药物的实验数据被用于验证,并使用Excel的Solver工具进行分析.

主要成果:

  • 修改后的双维布尔方程在匹配实验溶解和降水数据方面表现出很高的准确性.
  • 该模型成功地捕获了复杂的行为,如快速溶解,沉和重新溶解.
  • 这种方法被证明可以在各种条件下分析BCS类2a和2b药物的溶解概况.

结论:

  • 拟议的数学模型提供了一种强大而准确的方法来描述药物溶解和沉动力学.
  • 这种方法增强了对体外低溶性药物行为的理解.
  • 该模型在Excel中的易用性使其成为制药研究,配方开发和潜在地建立体外与体内相关性 (IVIVC) 的宝贵工具.