主体防御合成的营养调节:一个新的主体指导的抗菌治疗策略?
Melanie Whitmore1, Isabel Tobin1, Amanda Burkardt1
1Department of Animal and Food Sciences, Oklahoma State University, Stillwater, OK, United States.
Advances in nutrition (Bethesda, Md.)
|July 25, 2024
概括
饮食化合物可以通过增强宿主防御 (HDPs) 来提高自然抗菌防御. 这种方法提供了一种有希望的策略,可以在不引起炎症的情况下对抗抗菌素耐药性.
科学领域:
- 免疫学 免疫学 免疫学
- 营养科学 营养科学
- 微生物学 微生物学
背景情况:
- 抗菌素耐药性是一个日益增长的全球健康威胁,需要新的治疗方法.
- 主体防御 (HDPs) 对于天生的免疫力至关重要,具有抗微生物和免疫调节功能.
- 饮食化合物可以调节内源性HDP合成,提供一个潜在的策略来加强宿主防御.
研究的目的:
- 系统地审查各种饮食化合物如何调节HDPs的合成.
- 阐明这些化合物的作用机制及其协同效应.
- 评估饮食HDP诱导作为治疗传染病和抗菌素耐药性的治疗策略的潜力.
主要方法:
- 对饮食化合物和HDP合成研究的综合文献综述.
- 分析不同饮食化合物 (如SCFA,维生素,益生菌) 影响HDP基因表达的机制.
- 来自动物模型的证据的评估,证明了HDP诱导化合物的有效性.
主要成果:
- 许多饮食化合物,包括短链脂肪酸,维生素,矿物质和益生菌,增强内源性HDP的产生.
- 在不同类别的化合物之间观察到的协同效应放大了HDP合成和抗病能力.
- 用HDP诱导化合物的食补充剂在各种动物物种中显示出对感染的保护作用.
结论:
- 内源性HDP合成的营养调节代表了一种有希望的宿主导策略,用于打击传染病和抗菌素耐药性.
- 这种方法可以增强先天免疫力和屏障功能,而不会引起炎症或促进微生物耐药性.
- 诱导HDP的饮食化合物,特别是在组合中,对人类和动物的未来抗菌疗法具有重大潜力.
更多相关视频
08:58Analyzing Beneficial Effects of Nutritional Supplements on Intestinal Epithelial Barrier Functions During Experimental Colitis
Published on: January 5, 2017
12.2K
09:51Screening Bioactive Nanoparticles in Phagocytic Immune Cells for Inhibitors of Toll-like Receptor Signaling
Published on: July 26, 2017
12.4K
相关概念视频
Antimicrobial Proteins
965
Antimicrobial proteins are important components of the immune system. They aid the body in combating pathogens by either killing them directly or hindering their replication processes. Four main types of antimicrobial substances are interferons, the complement system, iron-binding proteins, and antimicrobial proteins.
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
965
Defense Against Bacterial Pathogens
1.4K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
1.4K
Inflammatory Response
1.9K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
1.9K
Defense Mechanism Against Infection
6.5K
Natural flora, body system defenses, and inflammation are natural barriers of the body against infectious agents regardless of previous exposure. Normal floras of the human body refer to the microbial population that colonizes the skin and mucous membranes.
In addition, many body organ systems have unique defenses against infection. The skin is an intact, multilayered surface preventing invasion by microorganisms unless impaired. Mucous membranes lining the mouth, nose, and eyelids are barriers...
In addition, many body organ systems have unique defenses against infection. The skin is an intact, multilayered surface preventing invasion by microorganisms unless impaired. Mucous membranes lining the mouth, nose, and eyelids are barriers...
6.5K
Defenses Against Pathogens and Herbivores
23.5K
Plants present a rich source of nutrients for many organisms, making it a target for herbivores and infectious agents. Plants, though lacking a proper immune system, have developed an array of constitutive and inducible defenses to fend off these attacks.
23.5K
