在精神分裂症和精神病性双相情感障碍之间,在丘脑,海马体和环状皮质的子区域中存在不同的结构连接模式
Peiyu Cao1, Yuting Li2, Yingbo Dong1
1Department of Psychiatry, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing Brain Hospital, Nanjing 210000, Jiangsu, China.
精神分裂症 (SCZ) 和精神双极障碍 (PBD) 显示出明显的边缘系统结构连接性障碍. 大脑网络中的这些差异可能有助于区分这些复杂的精神病障碍.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 脑部成像 脑部成像
背景情况:
- 精神分裂症 (SCZ) 和精神分裂双极障碍 (PBD) 呈现重叠的症状,使临床区分复杂化.
- 边缘系统在情绪调节和认知功能中起着至关重要的作用,其结构完整性在精神疾病中经常受到损害.
研究的目的:
- 研究和比较SCZ和PBD个体的边缘系统内的结构连接模式.
- 为了确定与SCZ和PBD中精神症状相关的边缘系统中的特定区域干扰.
主要方法:
- 分析了来自146名SCZ,160名PBD和145名健康对照 (HC) 参与者的结构MRI (sMRI) 数据.
- 一种数据驱动的方法将关键的边缘区域 (海马体,丘脑,下丘脑,杏仁体,带膜皮层) 分为子区域.
- 结构连接在全球和节点水平上进行了评估,并使用简要精神病学评分表 (BPRS) 与精神病症状严重程度相关联.
主要成果:
- 与HC相比,SCZ和PBD组均表现出全球效率,局部效率和聚类系数的降低,以及边缘网络中的路径长度的增加.
- 与PBD患者相比,SCZ患者在这些网络指标中表现出更明显的破坏.
- 显著的结构性干扰在海马体和丘脑中最为突出,与特定的精神病症状有明显的相关性.
结论:
- 这项研究揭示了SCZ和PBD的边缘系统内明显的结构连接性改变.
- 这些发现提供了关于神经病理基础的见解,这可能有助于区分SCZ和PBD.
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