再组合带状疹疫苗与更低的痴呆风险有关
Maxime Taquet1,2, Quentin Dercon3, John A Todd4
1Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, UK. maxime.taquet@psych.ox.ac.uk.
Nature medicine
|July 25, 2024
概括
新的重组带状疹疫苗显著降低了痴呆症风险,在接种疫苗后提供大约164个额外的无诊断日. 这种保护优于较旧的活带状疹疫苗和常见流感或Tdap疫苗.
科学领域:
- 神经学 神经学
- 免疫学 免疫学 免疫学
- 公共卫生 公共卫生
背景情况:
- 新出现的证据表明,活疹疫苗可能提供痴呆症保护.
- 活带状疹疫苗的生产停止,取而代之的是复合疫苗.
- 重组带状疹疫苗对痴呆的保护作用尚不清楚.
研究的目的:
- 为了比较活体和重组带状疹疫苗之间的痴呆风险.
- 评估复合带状疹疫苗与痴呆风险的关联.
- 评估复合带状疹疫苗与其他常见疫苗相比,是否提供对痴呆的保护.
主要方法:
- 利用活体和重组带状疹疫苗之间过渡的自然实验.
- 在接受重组和活带状疹疫苗的个体中比较痴呆风险.
- 分析了与重组带状疹疫苗和流感疫苗以及破伤风-白-咳疫苗相关的痴呆风险.
主要成果:
- 重组带状疹疫苗与接种疫苗后长达6年的痴呆症风险明显降低有关.
- 再组合疫苗的使用与无诊断时间增加17% (增加164天) 相关联.
- 与流感和Tdap疫苗相比,复合带状疹疫苗的痴呆风险较低,女性的效果更大.
结论:
- 再组合带状疹疫苗表明与降低痴呆风险的显著关联.
- 研究结果表明,复合带状疹疫苗可能具有神经保护作用.
- 进一步研究机制和大规模试验是有必要的,以证实这些痴呆症保护益处.
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