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免疫球蛋白M检测对于麻疹,疹和红疹的适当性

Thomas D Filardo¹, Nina B Masters¹, Jessica Leung¹

¹Viral Vaccine Preventable Disease Branch; Division of Viral Diseases; National Center for Immunization and Respiratory Diseases; Centers for Disease Control and Prevention, Atlanta, Georgia.

American journal of preventive medicine

|July 25, 2024

概括

大多数免疫球蛋白M (IgM) 检测麻疹,疹和红疹免疫力是不合适的. 只有免疫球蛋白G (IgG) 测试应使用,除非怀疑急性疾病,提高诊断准确度.

科学领域:

* 临床诊断和实验室检测.
* 免疫学测定和血清学测试.

背景情况:

* 免疫球蛋白G (IgG) 测试是评估对麻疹,疹和红疹 (MMR) 免疫力的标准.
* 免疫球蛋白M (IgM) 检测MMR免疫力仅在怀疑急性疾病时是适当的.
* 在常规临床实践中MMRIgM测试的适当性需要评估.

研究的目的:

* 在国家行政数据集中评估麻疹,疹和红疹IgM测试的适当性.
*根据人口和地区分析MMR血清检测的趋势.

主要方法:

* 2019-2022年MMR实验室检测数据 (IgG,IgM,RT-PCR) 的分析.
*使用了HealthVerity的行政声明和实验室数据.
* 定义适当的IgM测试是将其与急性疾病的诊断代码一起使用.

主要成果:

*MMR IgM测试占血清学测试的一小部分 (2.1%3.3%).
* 适当的MMRIgM检测仅发生在10.2%-32.8%的病例中.
*女性和年轻人 (0-19岁) 的IgM测试对麻疹和更为频繁.

结论:

* 在2019-2022年期间,大多数MMR IgM测试被认为是不合适的.
*建议包括修改电子病历,以支持IgG测试进行免疫评估.
* 商业实验室应促进提供者获得用于MMR免疫评估的仅IgG测试.

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