相关实验视频

Updated: Jun 19, 2025

Spontaneous Murine Model of Anaplastic Thyroid Cancer

Spontaneous Murine Model of Anaplastic Thyroid Cancer

Published on: February 3, 2023

右心房心肌瘤与恶性转变为不分化肉瘤:一个病例报告

Ryo Kaimori¹, Haruto Nishida², Yuzo Oyama³

¹Department of Diagnostic Pathology, Faculty of Medicine, Oita University, Idaigaoka 1-1, Hasama machi, Yufu City, Oita, Japan; Department of Forensic Medicine, Faculty of Medicine, Oita University, Idaigaoka 1-1, Hasama machi, Yufu City, Oita, Japan.

Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology

|July 25, 2024

概括

心脏肌瘤 (CM) 恶性转化为肉瘤是罕见的. 本病例报告详细介绍了心脏肌瘤与未分化的多形肉瘤,突出了这些良性瘤的潜在,尽管不常见的恶性途径.

科学领域:

心血管病理学心血管病理学
手术瘤学手术瘤学
瘤生物学瘤生物学

背景情况:

心脏肌瘤 (CM) 是一种良性心脏瘤,通常表现为肌瘤组织学.
恶性转变的CM是极其罕见的,记录的病例有限.
了解CM的潜在恶性途径对于准确的诊断和患者管理至关重要.

研究的目的:

为了记录和描述一种罕见的恶性转变心脏肌瘤病例.
研究区分良性和瘤组分的组织学和免疫组织化学特征.
为了解CM恶性进化的潜力做出贡献.

主要方法:

在89岁的男性患者的右心房瘤的手术切除.
组织病理学检查显示了明显的myxomatous和sarcomatous区域.
免疫组织化学 (IHC) 分析包括calretinin,MDM2,Ki-67和p53表达.
组织学发现与临床表现和患者病史的相关性.

主要成果:

切除的瘤表现出myxomatous特征 (calretinin阳性细胞) 和一个sarcomatous组件 (表皮状/状细胞与异型).
免疫组织化学显示出不同的特征:MDM2阳性和更高的Ki-67和p53指数仅在肉瘤区域观察到.
菌和肉区域之间的过渡在组织学上是无的.

结论:

这些发现支持诊断心肌瘤与恶性转变为不分化形肉瘤.
这一案例突显了良性心肌瘤可能进展为肉瘤的罕见但可能的情况.
需要进一步的研究来阐明CM恶性转变的机制和频率.

关键词:

心脏神经瘤是什么心脏神经瘤恶性变化恶性变化恶性转变的恶性转变

更多相关视频

Magnetic Resonance-Guided High Intensity Focused Ultrasound Generated Hyperthermia: A Feasible Treatment Method in a Murine Rhabdomyosarcoma Model

Magnetic Resonance-Guided High Intensity Focused Ultrasound Generated Hyperthermia: A Feasible Treatment Method in a Murine Rhabdomyosarcoma Model

Published on: January 13, 2023

Cardiac Magnetic Resonance for the Evaluation of Suspected Cardiac Thrombus: Conventional and Emerging Techniques

Cardiac Magnetic Resonance for the Evaluation of Suspected Cardiac Thrombus: Conventional and Emerging Techniques

Published on: June 11, 2019

相关概念视频

Tumor Progression

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...

Metastasis

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...

Mechanism of Cardiac Arrhythmias

Mechanism of Cardiac Arrhythmias

Arrhythmias are irregular heart rhythms occurring when the heart's electrical impulses become abnormal. These disturbances can lead to various symptoms, depending on their severity and the underlying cause. Some common factors contributing to arrhythmias include hypoxia, ischemia, electrolyte imbalances, excessive catecholamine exposure, drug toxicity, and muscle overstretching. Arrhythmias can be classified into two main types based on the rate and site of origin of abnormal heart rhythms.