服装中的化学物质暴露的健康风险 - 非受监管的化芳香化合物
Josefine Carlsson1, Awat Dostberg1, Tim Åström1
1Department of Materials and Environmental Chemistry, Stockholm University, SE-106 91, Stockholm, Sweden.
Chemosphere
|July 25, 2024
概括
织污染物迁移到皮肤上,可以被吸收,其中一些显示出致变种和皮肤敏感的影响. 虽然单个化学品的风险很低,但服装中的复杂混合物可能会由于长时间暴露而造成健康风险.
科学领域:
- 环境化学环境化学
- 毒理学 毒理学 毒理学
- 皮肤病学 皮肤病学
背景情况:
- 织工业使用许多化学物质,其中一些是化污染物.
- 人们对这些织污染物的生物可用性和危险性质存在担忧.
研究的目的:
- 调查常被检测到的化织污染物的生物利用性和危险性质.
- 为了评估体外皮肤吸收,突变性潜力和皮肤敏感作用.
主要方法:
- 在体外释放到人造汗水和皮肤吸收.
- 使用艾姆斯试验进行突变性评估.
- 通过反应性测定和基于细胞的测试来评估皮肤敏感性.
主要成果:
- 所有测试的化合物都从织品迁移到人造汗水中,并被皮肤吸收.
- 迁移值明显高于之前报告的文献值.
- 两种化合物显示出突变效应;另外两种化合物被确定为皮肤敏感剂,一种是由于转化产品.
- 皮肤过敏和非致癌效应的个体复合风险很低.
结论:
- 化织污染物具有生物可用性和危险性质.
- 虽然单个化学品的风险似乎很低,但服装中的复杂混合物可能会由于每天广泛暴露而造成健康风险.
- 需要对其他普遍存在的化学物质及其在服装中的协同作用进行进一步的研究.
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