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2型糖尿病患者中的维生素D和心力衰竭风险:观察性和门德尔随机化研究
Xue Chen1, Jiajing Xu2, Zhenzhen Wan1
1Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, Ministry of Education Key Lab of Environment and Health, and State Key Laboratory of Environment Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
较高的维生素D水平与2型糖尿病患者心力衰竭风险降低有关. 维持足够的维生素D可能有助于预防心力衰竭.
科学领域:
- 内分泌学 在内分泌学.
- 心脏病学 心脏病学
- 营养科学 营养科学
背景情况:
- 维生素D缺乏在2型糖尿病 (T2D) 中很普遍.
- 目前关于维生素D和T2D心力衰竭 (HF) 风险的证据有限且不一致.
研究的目的:
- 研究2型糖尿病患者血清25-基维生素D [25(OH) D]与HF风险之间的关联.
- 通过观察和门德尔随机化 (MR) 框架来检查这些关联.
主要方法:
- 用Cox回归方法对来自英国生物库的15226名T2D参与者的观察分析.
- 孟德尔的随机化分析涉及11,260名T2D参与者,使用25(OH) D度的遗传风险得分.
- 通过电子健康记录来确定HF发病率.
主要成果:
- 血清25(OH) D显示与HF风险的非线性反向关联,平稳在50nmol/L左右.
- 较高的血清25(OH) D水平 (50.0-74.9nmol/L和>75nmol/L) 与水平<25nmol/L相比,与显著降低的HF风险有关.
- 对MR的分析表明,基因预测的25(OH) D增加7%与T2D中HF风险降低36%有关.
结论:
- 在T2D患者中,较高的血清25(OH) D与降低HF风险有关.
- 门德尔的随机分析表明,维生素D状况与HF风险之间存在潜在的因果关系.
- 维持足够的维生素D水平可能有助于预防T2D患者中HF.
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