产前和产后母亲IBD状态对后代IBD风险的影响:基于人口的队列研究
Linéa Bonfils1, Gry Poulsen2, Manasi Agrawal2,3
1Department of Clinical Medicine, Aalborg University, Copenhagen, Denmark lineab@dcm.aau.dk.
Gut
|July 25, 2024
概括
在分娩前确诊的父母炎症性肠病 (IBD) 显著增加后代IBD风险. 这突出了IBD发展的遗传和早期环境因素,而不是子宫内炎症.
科学领域:
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
- 遗传学 遗传学 是一个
背景情况:
- 在子宫内产生的孕妇炎症可能会影响免疫发育和疾病易感性.
- 炎症性肠病 (IBD) 包括克罗恩氏病和性结肠炎,这些都是影响消化道的慢性疾病.
研究的目的:
- 为了确定产前母亲IBD诊断是否会提高后代IBD风险,与分娩后的诊断相比.
- 为了比较父亲IBD状态对后代IBD风险的影响.
主要方法:
- 利用丹麦的健康登记册来识别1997年至2022年间出生的儿童及其父母的IBD状态.
- 使用Cox比例危险回归,根据日历时期和分娩方式进行调整,以根据父母IBD诊断时间评估后代的IBD风险.
主要成果:
- 在分娩前患有IBD的母亲的后代患有IBD风险增加了6.27倍 (aHR).
- 产后患有IBD的母亲的后代患有IBD的风险增加了3.88倍 (aHR).
- 在分娩前,父亲的IBD显示风险增加了5.26倍 (aHR),分娩后风险增加了3.73倍 (aHR).
结论:
- 父母在分娩前诊断出IBD与后代IBD风险大大增加有关.
- 研究结果表明,遗传倾向和早期环境因素对IBD风险的贡献更大,而不是子宫内炎症.
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