在有或没有海马硬化症的时叶中,中国口语流利性缺陷:一项多规模研究
Kangrun Wang1,2,3,4, Fangfang Xie5, Chaorong Liu1
1Department of Neurology, Xiangya Hospital, Central South University, Changsha 410008, China.
概括
一个新的汉字口语流任务有效地识别了叶 (TLE) 中的口语流缺陷. 患有海马硬化症的患者表现出大脑连接受损,而没有它的人表现出增强的连接,这表明了补偿策略.
科学领域:
- 神经科学是一个神经科学.
- 认知心理学 认知心理学
- 医疗成像医学成像
背景情况:
- (TLE) 是一种神经疾病,通常与认知障碍有关,包括口语流的缺陷.
- 了解TLE语言流利性缺陷的具体模式,特别是关于海马硬化症 (HS) 的理解,对于诊断和管理至关重要.
- 现有的口语流任务可能无法完全捕捉不同语言群体的认知功能的细微差别,例如说中文的人.
研究的目的:
- 在TLE患者中评估语音口语流利任务 (VFC) 的中文字符版本.
- 研究具有海马硬化症 (TLE-HS) 的TLE与没有海马硬化症 (TLE-NHS) 的TLE中明显的口语流性缺陷模式.
- 使用功能磁共振成像 (fMRI) 探索这些缺陷的神经支柱.
主要方法:
- 一项涉及30名TLE-HS患者,28名TLE-NHS患者和29名健康对照 (HC) 的横截面研究.
- 参与者在fMRI期间完成了VFC任务,允许分析大脑激活,停用,功能连接和前额和部区域的网络属性.
- 基于功能性MRI数据,使用神经网络分类模型来区分TLE-HS和TLE-NHS.
主要成果:
- 与对照组相比,TLE-HS和TLE-NHS组在VFC任务中表现出显著的激活和停用缺陷.
- 前下旋的功能连接性,中心度和社区特征在TLE-HS中受损,但在TLE-NHS中保留或增强.
- VFC任务显示了临床应用的巨大潜力,神经网络模型在诊断海马硬化时实现了0.90曲线下的面积.
结论:
- 中国字母口语流利 (VFC) 任务是评估TLE中华语患者语音口语流利的有效和临床适用工具.
- 语音电路中的功能连接受损的特点是TLE-HS,而TLE-NHS中的增强连接表明了口头搜索的补偿机制.
- 这些发现突出了基于海马硬化存在或不存在的TLE中差异神经网络变化,为TLE病理生理学和认知补偿提供了洞察力.
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