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Updated: Jun 19, 2025

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在聚合酶中活动切换的结构基础决定了let-7前miRNAs的命运

Gangshun Yi1,2, Mingda Ye3, Loic Carrique1

  • 1Division of Structural Biology, Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.

Nature structural & molecular biology
|July 25, 2024
PubMed
概括

终端尿基转移酶TUT7和TUT4调节了let-7微RNA (miRNA) 的成熟或降解. 多能因子LIN28A指导TUT7/4添加多个尿素,影响细胞命运和癌症.

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