在老年人中,肠道微生物特征和循环的新陈代谢标志是脆弱的标志

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Yanni Pu¹, Zhonghan Sun¹, Hui Zhang^2,3

¹State Key Laboratory of Genetic Engineering, Human Phenome Institute, School of Life Sciences, Zhongshan Hospital, Fudan University, Shanghai, China.

Nature aging

|July 25, 2024

概括

这项研究将肠道微生物和代谢物与老年人的脆弱性联系起来,确定了与健康状况和死亡风险相关的Clostridium和Faecalibacterium prausnitzii等特定物种.

科学领域:

老年学是一门学科.
微生物组研究微生物组研究
代谢学代谢学代谢学

背景情况:

虚弱意味着系统间与年龄相关的生理衰退.
肠道微生物群在健康衰老中的作用尚未完全理解.
了解这些因素对于促进健康衰老至关重要.

研究的目的:

为了研究肠道微生物组成,血代谢和老年人的脆弱性之间的关联.
为了确定特定的微生物物种和与脆弱性严重程度相关的代谢物.
探索基于微生物群的标志物的潜力,以预测老龄化人口中的死亡率.

主要方法:

从1821名老年人 (62-96岁) 的33个健康项目计算的脆弱指数 (FI).
通过肠道代谢基因组和血代谢基因组数据进行了多组学分析.
在两个外部队列中验证了微生物物种与FI的关联.

主要成果:

确定了18种微生物物种和17种与脆弱性严重程度相关的代谢物,女性的联系更强.
包括Clostridium和Faecalibacterium prausnitzii在内的9种物种显示出与FI.的可再生关联.
一个复合的微生物评分预测了2年死亡率 (aHR 2.86).

结论:

肠道微生物群的组成与老年人的虚弱显著相关.
特定的微生物物种和代谢物可以作为脆弱和衰老的生物标志物.
基于微生物群的策略对脆弱性风险分层和预测死亡率有希望.

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