基于乙醇胺的蛋白质表面活性剂离子液体对在多种温度下对乙氨基的溶解度的影响:测量和热力学相关性
Parisa Akbarzadeh Gondoghdi1, Hemayat Shekaari2, Masumeh Mokhtarpour1,3
1Department of Physical Chemistry, University of Tabriz, Tabriz, Iran.
BMC chemistry
|July 25, 2024
概括
这项研究研究了三种以乙醇胺劳拉特为基础的蛋白离子液 (PILs) 中的乙氨基溶性. 结果为制药应用提供了关键数据,指导为药物输送系统选择最佳的PIL.
科学领域:
- 材料科学 材料科学 材料科学
- 物理化学 物理化学
- 制药科学 制药科学
背景情况:
- 蛋白离子液体 (PILs) 具有独特的热物理特性,在化学和制药行业具有价值.
- PIL显示了提高药物溶解性和输送系统的巨大潜力.
- 了解溶解物-溶剂相互作用是开发先进药物配方的关键.
研究的目的:
- 为了确定乙氨基 (ACP) 在三种以乙醇胺酸为基础的PIL中的溶解度:[MEA]La,[DEA]La和[TEA]La.
- 评估各种热力学和经验模型在关联非洲和非洲国家和地区溶解度数据方面的表现.
- 分析在选定的PIL中ACP溶解的热力学特性.
主要方法:
- 在大气压下,在298.15313.15 K的温度范围内,使用摇法进行了溶解度测量.
- 使用威尔逊,e-NRTL,范特霍夫-朱伊班-阿克里和修改的阿佩尔布拉特-朱伊班-阿克里模型,对实验溶解度数据进行了相关联.
- 用范特霍夫和吉布斯方程计算了热力学特性.
主要成果:
- 在[MEA]La,[DEA]La和[TEA]La药片中成功测量了乙氨基的溶解度.
- 模型性能各不相同,威尔逊和修改的Apelblat-Jouyban-Acree通常显示出对[MEA]La的更好的相关性,而威尔逊和范特霍夫-Jouyban-Acree则更喜欢[DEA]La和[TEA]La.
- 热力学分析提供了对这些PIL中的乙氨基溶解过程的见解.
结论:
- 该研究提供了在特定PIL中对乙氨基的基本溶解度数据,这对于制药配方开发至关重要.
- 这些发现突出了各种模型在预测溶解度方面的差异性表现,有助于选择合适的相关工具.
- 这项研究有助于理解PILs作为可行的媒介,用于提高药物溶解度和输送.
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