一项随机前性研究,比较了小体积肠道制剂对中国结肠镜准备的效果
Jianwei Shen1, Hong Sheng2, Hui He3
1Department of Gastroenterology, Ningbo Medical Center Li Huili Hospital, Ningbo, Zhejiang, China.
Scandinavian journal of gastroenterology
|July 26, 2024
概括
与3L聚乙烯糖醇 (PEG) 相比,硫酸/酸 (SPMC) 为结肠镜准备提供了优越的患者接受度和耐受性. 这两种肠道制备方法在清洗和输管时间方面都表现出类似的有效性.
科学领域:
- 胃肠病学 胃肠病学
- 内镜检查是指内镜检查.
- 临床试验 临床试验
背景情况:
- 有效的肠道准备对于成功的结肠镜检查至关重要.
- 传统的肠道清洁剂,如3L聚乙烯甘醇 (PEG),可能具有不理想的患者耐受性.
- 新型药物如硫酸盐/酸 (SPMC) 旨在改善患者的体验.
研究的目的:
- 为了比较SPMC与3L PEG用于结肠镜肠道准备的疗效和患者报告的结果.
- 评估二甲基康对两种药物的有效性和耐受性的影响.
- 评估二次结果,包括结肠清洁,管输管时间,腺瘤检测率 (ADR) 和不良事件.
主要方法:
- 一个多中心,前性,随机对照研究.
- 成年患者被随机分为四组:SPMC,SPMC用二甲基,3L PEG和3L PEG用二甲基.
- 使用波士顿肠道准备量表 (BBPS) 评估结肠清洁;二级终点包括泡得分,管输液时间,ADR,安全性和合规性.
主要成果:
- 在SPMC和3L PEG组之间没有观察到可接受的肠道清洗,BBPS得分或内输管时间的显著差异.
- 与3L PEG.相比,SPMC显示患者报告的可接受性和耐受性显著更高.
- 在SPMC组中,不良事件明显低于3L PEG组;在两个主要组中,ADR超过30%.
结论:
- SPMC是结肠镜肠道准备的可行替代品,在3L PEG.上提供了较好的患者接受性和耐受性.
- 在SPMC和3L PEG.之间,肠道清洁效率和内输管时间是可比的.
- 在这项研究中,dimethicone对本研究的主要结局没有显著影响.
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