相关实验视频

Updated: Jun 19, 2025

Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo

Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo

Published on: January 7, 2019

一个免疫调节器增强的乳球菌乳酸菌平台,用于增强的in situ瘤疫苗

Mengna Sun^1,2, Tianyu Shi^1,2, Subiyinuer Tuerhong^1,2

¹Department of Comprehensive Cancer Centre, Nanjing Drum Tower Hospital, Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, 210008, China.

Advanced healthcare materials

|July 26, 2024

概括

这项研究介绍了一种免疫调节器增强的乳球菌乳腺菌 (IBL) 策略,用于在位癌症疫苗接种. 这种新的方法通过持续分散免疫激动剂来增强抗瘤免疫力,显著抑制小鼠的瘤生长.

科学领域:

免疫学免疫学免疫学
癌症研究癌症研究
生物技术是生物技术.

背景情况:

有效的本位癌症疫苗接种需要在瘤内持续分散免疫激动剂.
益生菌提供了一个潜在的平台,可以提供免疫调节剂,以提高治疗疗效.

研究的目的:

开发一种免疫调节剂增强的乳球菌 (IBL) 策略,用于在位癌症疫苗接种.
评估一种新型疫苗 (OR@Lac) 在增强抗瘤免疫反应和抑制瘤生长方面的疗效.

主要方法:

改造的乳球菌 (Lactococcus lactis) 携带和输送OX40激动剂和溶解剂 (OR@Lac) 内.
评估了瘤和淋巴结中的免疫细胞激活 (树突细胞,细胞毒性T淋巴细胞).
研究了OR@Lac与ibrutinib (骨髓菌衍生抑制细胞抑制剂) 的联合治疗.

主要成果:

OR@Lac促进了免疫调节剂的局部保留和持续分散.
该疫苗激活了关键的抗瘤免疫成分,包括树突细胞和细胞毒性T淋巴细胞.
在小鼠中,OR@Lac显著抑制瘤生长和延长存活时间,与ibrutinib结合时有效性得到增强.

结论:

免疫调节剂增强的乳球菌乳腺菌 (IBL) 策略代表了在位瘤疫苗接种的一个有前途的方法.
这种输送系统激发了其他治疗剂在癌症治疗中的未来应用.

关键词:

药物输送是药物输送的过程.乳球球菌 (lactococcus lactis) 是一种乳球菌.瘤免疫疗法免疫疗法瘤微环境是一个微环境.癌症疫苗,瘤疫苗,以及其他疾病.

更多相关视频

Experimental Melanoma Immunotherapy Model Using Tumor Vaccination with a Hematopoietic Cytokine

Experimental Melanoma Immunotherapy Model Using Tumor Vaccination with a Hematopoietic Cytokine

Published on: February 24, 2023

Intralymphatic Immunotherapy and Vaccination in Mice

Intralymphatic Immunotherapy and Vaccination in Mice

Published on: February 2, 2014

相关概念视频

Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

Cancer Vaccines

Cancer Vaccines

Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...