与自闭症谱系障碍相关的新生儿风险因素:一个总体审查
Amir Mohammad Salehi1, Erfan Ayubi2, Salman Khazaei3
1Student Research Committee, Hamadan University of Medical Sciences School of Medicine, Hamadan, Iran.
Clinical and experimental pediatrics
|July 26, 2024
概括
新生儿风险因素,如先天性心脏病,巨,低出生体重,黄和男性性别与自闭症谱系障碍 (ASD) 有关. 建议对患有这些风险因素的婴儿进行早期查.
科学领域:
- 神经发育障碍 神经发育障碍
- 儿科医学 儿科医学 儿科医学
- 遗传学和表观遗传学
背景情况:
- 自闭症谱系障碍 (ASD) 是一种复杂的神经发育状况,其特点是社会沟通缺陷和重复行为.
- 早期识别风险因素对于及时干预和支持至关重要.
研究的目的:
- 进行对元分析和系统审查的总体审查.
- 评估与自闭症谱系障碍发展相关的新生儿风险因素.
主要方法:
- 在国际数据库 (PubMed,Scopus,Web of Science) 进行系统搜索,截至2022年4月.
- 使用随机效应模型计算赔率比率 (OR) 和95%置信区间 (CI).
- 使用A测量工具来评估系统审查 (AMSTAR2) 检查清单评估研究质量.
主要成果:
- 包括6个元分析,包括207,221名患有自闭症儿童和超过2200万名神经类型儿童.
- 有关证据表明,先天性心脏病,巨,低出生体重,非常低出生体重,对于妊娠年龄来说小,黄,男性性别和低1分钟的阿巴格分数与ASD风险增加有关.
- 包含的元分析的方法质量各不相同,其中3项被评为非常低,2项被评为低,1项被评为中等.
结论:
- 几种新生儿因素与自闭症谱系障碍的风险增加有关.
- 临床医生应在儿科查期间考虑这些已识别的风险因素.
- 可能需要进一步的研究来澄清因果途径,并完善风险评估.
相关概念视频
01:19Autism Spectrum Disorder
79
Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
79
01:30Attention-Deficit/Hyperactivity Disorder
51
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
51
01:07Teratogenicity
2.4K
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
2.4K