在创伤后应激障碍中中介前额叶皮层神经递质异常,有或没有伴随性严重抑郁症的并发症
Kelley M Swanberg1,2, Hetty Prinsen2, Christopher L Averill3,4,5,6
1Biomedical Engineering, Columbia University School of Engineering and Applied Science, New York, NY, USA.
NMR in biomedicine
|July 26, 2024
概括
重度抑郁症 (MDD) 在创伤后应激障碍 (PTSD) 患者中显著影响大脑代谢物异常. 中部前额叶皮质中的谷氨酸和谷氨胺水平发生了变化,有助于将患者与对照区分开来.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 医疗成像医学成像
背景情况:
- 创伤后应激障碍 (PTSD) 是一种与创伤性压力相关的慢性疾病.
- 之前的质子磁共振光谱 (1H MRS) 在较低场强度的研究表明在PTSD中存在谷氨酸代谢变化.
- 伴随性重度抑郁症 (MDD) 对PTSD中这些大脑代谢物异常的影响仍未得到充分探索.
研究的目的:
- 为了研究大脑代谢物度 (谷氨酸,谷氨胺,GABA,谷氨) 在中部前额叶皮质 (mPFC) 使用高场 7 特斯拉 1H MRS.
- 检查并发性MDD对患有PTSD的个体mPFC代谢物概况的影响.
- 评估这些代谢物模式的诊断潜力,以便对PTSD和/或MDD患者进行分类.
主要方法:
- 雇佣了7特斯拉1HMRS来量化mPFC中的谷氨酸,谷氨酸,GABA和谷氨.
- 研究了四组:患有MDD的PTSD (PTSD+MDD+),没有MDD的PTSD (PTSD+MDD-),没有PTSD的MDD (PTSD-MDD+) 和健康的对照 (PTSD-MDD-).
- 使用监督分类来区分患者组与基于代谢物度的对照组.
主要成果:
- 与健康对照组相比,患有PTSD的个体显示GABA与谷氨胺比率降低,但没有单个代谢物异常.
- 并发性MDD,而不是单独的PTSD诊断,与增加的mPFC谷氨酸和减少的谷氨酸:谷氨酸比率有显著的关联.
- 与健康对照人群相比,所有患有PTSD和/或MDD的参与者都在集体上表现出较低的谷氨水平.
- 代谢物模式,特别是谷氨,谷氨和肌醇,使患者从对照组中分类,准确度超过80%.
结论:
- 重度抑郁症是影响中部前额叶皮层中PTSD患者的谷氨酸代谢异常的一个重要因素.
- 高场1H MRS可以检测PTSD和伴随性MDD中明显的代谢物变化.
- 在mPFC中的代谢物概况显示了开发PTSD和相关精神疾病的客观生物标志物的潜力.
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