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Updated: Jun 19, 2025

In Vitro Assay to Study Tumor-macrophage Interaction

In Vitro Assay to Study Tumor-macrophage Interaction

Published on: August 1, 2019

与瘤相关的巨细胞:瘤微环境中的先天性免疫系统的哨兵变得疯狂

Shaivy Malik¹, Niti Sureka¹, Sana Ahuja¹

¹Department of Pathology, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, New Delhi, India.

Cell biology international

|July 26, 2024

概括

瘤相关巨细胞 (TAMs) 是癌症的关键参与者,影响瘤生长和治疗. 重编程TAM和使用化学抗原受体巨细胞 (CAR-M) 显示出有效的癌症治疗的希望.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
癌症生物学癌症生物学

背景情况:

瘤微环境 (TME) 极大地影响癌症的发病,进展和治疗反应.
瘤相关巨细胞 (TAMs) 在TME中表现出可塑性,充当瘤生长的促进者和抑制者.
TAMs的亲瘤功能包括促进血管生成,免疫抑制和转移.

研究的目的:

审查TAMs在瘤微环境中的多方面的作用.
探索针对TAM的治疗策略,重点关注重编程和新的方法.
讨论化学抗原受体巨细胞 (CAR-M) 在固体瘤治疗中的潜力.

主要方法:

对TAM功能和治疗干预措施的文献综述.
对TAM向疗法的临床前和临床数据的分析.
对巨细胞 (CAR-M) 应用的化学抗原受体 (CAR) 技术的探索.

主要成果:

TAMs表现出可塑性,采用可以促进或抑制瘤进展的表型.
像CSF1R抑制剂,CD40激动剂和CD47阻断等治疗策略在调节TAMs方面表现有前途.
化学抗原受体-巨细胞 (CAR-M) 代表了一种针对固体瘤的新方法,第三代技术正在不断发展.

结论:

了解TME中的TAM动态对于开发有效的癌症疗法至关重要.
重编程TAM和利用CAR-M技术为癌症治疗提供了有前途的途径.
进一步的研究和临床试验对于优化TAM向策略和改善患者治疗结果至关重要.

关键词:

在CAR-M中,它是最重要的.一个单细胞单细胞.瘤微环境是一个微环境.与瘤相关的巨细胞.

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