模式,临床特征和家族史对前列腺癌前列腺特异抗原的影响:多中心研究
Chinonyerem O Iheanacho1, Valentine U Odili2, Glen E Enakirerhi3
1Department of Clinical Pharmacy and Public Health, Faculty of Pharmacy, University of Calabar, Calabar, Nigeria.
American journal of men's health
|July 26, 2024
概括
前列腺癌 (PCa) 往往在尼日利亚男性的晚期呈现,家族史在诊断时没有影响前列腺特异性抗原 (PSA) 水平. 早期查策略对于更好的结果至关重要.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 在瘤学瘤学.
- 公共卫生 公共卫生
背景情况:
- 前列腺癌 (PCa) 是撒哈拉以南非洲裔男性的重大健康问题.
- 了解尼日利亚的PCa模式和临床特征对于有针对性的干预至关重要.
- 在诊断时,家族病史对前列腺特异性抗原 (PSA) 水平的影响需要进行调查.
研究的目的:
- 评估尼日利亚前列腺癌的流行病学模式.
- 为了评估家族病史对PSA水平在PCa诊断时的影响.
- 描述尼日利亚前列腺癌患者的临床特征.
主要方法:
- 一项涉及200名参与者的横截面调查在尼日利亚进行了12个月.
- 数据收集包括患者采访和医院记录.
- 统计分析使用了SPSS版本 25,使用描述和推断统计数据 (P < .05被认为是显著的).
主要成果:
- 参与者的平均年龄为68.5岁;32.0%的人有PCa的积极家族史.
- 大多数患者 (70.0%) 呈现下尿路症状 (LUTS),下背部疼痛或腿部疼痛,表明疾病已晚.
- 癌症家族史在诊断时没有显著影响PSA水平 (p = .329);PCa在60-70.岁的男性中最常见.
结论:
- 尼日利亚的前列腺癌经常呈现于晚期或转移性阶段.
- 在这个人群中,癌症家族史似乎不是PSA水平在诊断时的预测指标.
- 迫切需要公共卫生政策和战略来促进早期前列腺癌查.
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