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Updated: Jun 19, 2025

High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines
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High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines

Published on: November 9, 2020

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酶可激活蛋白解的模块化开发,针对选择性蛋白降解和向癌症的奇默体

Yanchi Chen1,2, Lina Zhang1, Lincheng Fang1

  • 1State Key Laboratory of Chemical Oncogenomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen 518055, China.

JACS Au
|July 26, 2024
PubMed
概括

酶可激活蛋白质分解向嵌合体 (PROTACs) 选择性地降解癌细胞中的蛋白质. 这种新的方法尽量减少健康组织中的毒性,提供更安全的癌症治疗方法.

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