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相关概念视频

Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

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Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
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Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
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相关实验视频

Updated: Jun 19, 2025

Applying a Three-dimensional Uniaxial Mechanical Stimulation Bioreactor System to Induce Tenogenic Differentiation of Tendon-Derived Stem Cells
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Applying a Three-dimensional Uniaxial Mechanical Stimulation Bioreactor System to Induce Tenogenic Differentiation of Tendon-Derived Stem Cells

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组织工程介质干细胞结构通过抑制血管化来缓解肌病.

Dijun Li1,2,3, Jingwei Jiu1,2, Haifeng Liu1,2

  • 1Department of Orthopaedic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310006, China.

Bioactive materials
|July 26, 2024
PubMed
概括

组织工程干细胞 (TSCs) 通过抑制VEGF受体激活来限制肌病的病态血管化. 这种新的方法可以减少炎症并促进肌的愈合,为早期肌病症提供了有前途的治疗方法.

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Evaluation of Stem Cell Therapies in a Bilateral Patellar Tendon Injury Model in Rats
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Evaluation of Stem Cell Therapies in a Bilateral Patellar Tendon Injury Model in Rats

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Treatment of Osteochondral Defects in the Rabbit's Knee Joint by Implantation of Allogeneic Mesenchymal Stem Cells in Fibrin Clots
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Treatment of Osteochondral Defects in the Rabbit's Knee Joint by Implantation of Allogeneic Mesenchymal Stem Cells in Fibrin Clots

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相关实验视频

Last Updated: Jun 19, 2025

Applying a Three-dimensional Uniaxial Mechanical Stimulation Bioreactor System to Induce Tenogenic Differentiation of Tendon-Derived Stem Cells
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Treatment of Osteochondral Defects in the Rabbit's Knee Joint by Implantation of Allogeneic Mesenchymal Stem Cells in Fibrin Clots
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科学领域:

  • 生物医学工程 生物医学工程
  • 再生医学是一种再生医学.
  • 整形外科 整形外科 整形外科

背景情况:

  • 肌病症涉及慢性炎症和损伤,由不平衡的血管生成驱动.
  • 目前的干细胞疗法和支架在治疗肌病的有效性有限.
  • 针对早期的病理性血管化,为肌再生提供了一个潜在的治疗策略.

研究的目的:

  • 研究组织工程干细胞 (TSC) 与微载体支架相结合在治疗肌病的疗效.
  • 评估TSCs在限制过度血管化的潜力,并调节细胞炎症和合成蛋白质的特征.

主要方法:

  • 人类带介质干细胞 (hUC-MSCs) 用于产生TSC.
  • 在肌病模型中,TSC与微载体支架相结合,以限制血管化.
  • 在体外测试中评估了血管生成和血管内皮细胞的增殖.
  • 在体内研究涉及到局部注射TSCs的老鼠与原酶诱导的肌病.
  • 转录组测序被用来阐明潜在的机制.

主要成果:

  • 通过抑制VEGF受体激活,TSCs减少了体外血管生成和血管内皮细胞的增殖.
  • TSCs降低了细胞的炎症表达,同时增强了其合成化合物和原特性.
  • 在老鼠中,局部TSC注射显著减少了早期肌病的炎症和血管化.
  • 转录组分析确定了Rap1介导的血管抑制作为一个关键机制.

结论:

  • TSCs代表了一种新的治疗方法,用于抑制病态肌血管化.
  • 这一策略显示了通过调节血管生成和炎症来治疗早期肌病的前景.
  • 通过Rap1介导的途径为TSC疗效提供了机械的洞察力.