中年非洲男性的SHBG,自由和2型糖尿病风险:一项纵向研究
Ikanyeng D Seipone1, Amy E Mendham2,3,4, Karl-Heinz Storbeck5
1Biomedical Research Innovation Platform, South African Medical Research Council, Cape Town 7505, South Africa.
Journal of the Endocrine Society
|July 26, 2024
概括
性激素结合球蛋白 (SHBG) 水平预测中年非洲男性的失糖症. 然而,SHBG在艾滋病毒感染者 (MLWH) 中没有显示预测价值.
科学领域:
- 内分泌学和新陈代谢学
- 公共卫生 公共卫生
- 艾滋病毒研究 艾滋病毒研究
背景情况:
- 在中年非洲男性中,性激素结合球蛋白 (SHBG) 和自由 (自由T) 的纵向变化尚不清楚,特别是关于它们对葡萄糖代谢的影响.
- 研究这些荷尔蒙变化在艾滋病毒感染和没有艾滋病毒感染的男性是非常重要的,以了解失糖症和代谢障碍的差异性风险.
研究的目的:
- 检查黑人南非中年男性的SHBG和自由T水平的纵向变化,比较艾滋病毒感染者和未感染者的情况.
- 探索这些激素水平与失糖症和葡萄糖代谢参数发生率之间的关联.
主要方法:
- 一项对407名南非黑人中年男性 (322名没有艾滋病毒,85名艾滋病毒感染者) 进行的纵向研究,在基线时他们的禁食葡萄糖正常.
- 在基线和随访 (3.1 ± 1.5年) 测量了荷尔蒙水平 (SHBG,白蛋白,总);计算了自由T.
- 糖尿病和葡萄糖代谢 (胰岛素敏感性,胰岛素耐药性,β细胞功能) 在随访时使用口服葡萄糖耐受性测试进行评估.
主要成果:
- 在没有HIV的男性中,更高的基线SHBG与降低发生性失糖血的风险 (OR0.966) 以及改善胰岛素敏感性和β细胞功能有关.
- 在没有艾滋病毒的男性中,自由T水平并不能预测血糖失调.
- 在携带艾滋病毒的男性中,基线SHBG和自由T都与发生的失糖症或改变的葡萄糖代谢参数无关.
结论:
- 在没有艾滋病毒的中年非洲男性中,SHBG水平是发生失糖症的重要预测因素.
- 这种SHBG的预测值没有在艾滋病毒感染者中观察到,这表明艾滋病毒或其治疗对这种关联有潜在的影响.
- 需要进一步的研究,以阐明HIV感染者和无HIV感染者的这些差异背后的机制.
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