Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Targeting breast cancer with 1,2,4-trioxanes: synthesis, cytotoxicity, and molecular docking insights.

RSC advances·2026
Same author

Integrative transcriptional regulatory networks governing cereal root responses to heavy metals and drought.

Plant cell reports·2026
Same author

Decoding Enzyme-Inhibitor Kinetic Mechanisms by Isothermal Titration Calorimetry: The Case of SARS-CoV-2 3CL<sup>pro</sup>.

Analytical chemistry·2026
Same author

Impact of different occlusal schemes on temporomandibular joint health among edentulous patients in India.

Bioinformation·2026
Same author

Nickel binding shifts Helicobacter pylori HypA toward compact conformations.

Journal of inorganic biochemistry·2026
Same author

Microdebrider - Assisted management of central airway obstruction via rigid bronchoscopy: A preliminary study on safety and efficacy.

Lung India : official organ of Indian Chest Society·2026

相关实验视频

Updated: Jun 19, 2025

Growing Protein Crystals with Distinct Dimensions Using Automated Crystallization Coupled with In Situ Dynamic Light Scattering
09:15

Growing Protein Crystals with Distinct Dimensions Using Automated Crystallization Coupled with In Situ Dynamic Light Scattering

Published on: August 14, 2018

10.5K

通过激光衍射实现实时粒子大小分析的自动连续结晶平台.

Sayan Pal1, Arun Pankajakshan1, Maximilian O Besenhard1

  • 1Department of Chemical Engineering, University College London, Torrington Place, London WC1E 7JE, U.K.

Organic process research & development
|July 26, 2024
PubMed
概括

本研究介绍了一种用于实时粒子大小分析的自动化结晶平台,克服了制药制造业的瓶. 该系统能够在最小的实验力度下快速选结晶参数和结晶器设计.

更多相关视频

On-Chip Crystallization and Large-Scale Serial Diffraction at Room Temperature
07:42

On-Chip Crystallization and Large-Scale Serial Diffraction at Room Temperature

Published on: March 11, 2022

1.8K
Author Spotlight: Advancing Protein Structure Analysis for Drug Development
07:08

Author Spotlight: Advancing Protein Structure Analysis for Drug Development

Published on: March 8, 2024

3.4K

相关实验视频

Last Updated: Jun 19, 2025

Growing Protein Crystals with Distinct Dimensions Using Automated Crystallization Coupled with In Situ Dynamic Light Scattering
09:15

Growing Protein Crystals with Distinct Dimensions Using Automated Crystallization Coupled with In Situ Dynamic Light Scattering

Published on: August 14, 2018

10.5K
On-Chip Crystallization and Large-Scale Serial Diffraction at Room Temperature
07:42

On-Chip Crystallization and Large-Scale Serial Diffraction at Room Temperature

Published on: March 11, 2022

1.8K
Author Spotlight: Advancing Protein Structure Analysis for Drug Development
07:08

Author Spotlight: Advancing Protein Structure Analysis for Drug Development

Published on: March 8, 2024

3.4K

科学领域:

  • 制药工程 制药工程
  • 化学工程是化学工程的重要组成部分.
  • 过程自动化 过程自动化

背景情况:

  • 颗粒物处理和悬浮处理在制药行业中构成自动化挑战.
  • 抗溶剂结晶的发展受到耗时的实验选的阻碍.

研究的目的:

  • 为了展示一个完全自动化的模块化结晶平台.
  • 为了克服实时粒子大小分析和实验选方面的瓶.

主要方法:

  • 集成自动化结晶,样品制备和在线激光衍射 (LD) 分析.
  • 使用LabVIEW,Python和PharmaMV软件,并使用逻辑算法进行自动控制.
  • 采用一个封闭的撞击喷气结晶器用于布洛芬抗溶剂结晶.

主要成果:

  • 成功选了结晶过程参数和结晶器设计空间,使用最小的实验力度.
  • 实现了自动化操作和实时晶体尺寸分布可视化.
  • 证明了自动稀释,以避免在LD测量期间发生多次散射事件.

结论:

  • 开发的平台显著加快了抗溶剂结晶过程的选.
  • 能够有效地自动化制药制造中的颗粒大小分析.
  • 为优化结晶器设计和工艺参数提供了强大的解决方案.