关于CRISPR/Cas的图书统计分析:一种潜在的夏洛克·霍姆斯,用于疾病检测
Rohan Samir Kumar Sachan1, Adarsh Choudhary1, Inderpal Devgon1
1School of Bioengineering and Biosciences, Lovely Professional University, Phagwara, India.
Frontiers in molecular biosciences
|July 26, 2024
概括
克里斯普尔技术已经改变了疾病检测. 这份对1992-2023年CRISPR研究的文献分析显示了显著的增长,特别是从2018-2023年,突出了全球关键贡献者和有影响力的研究.
科学领域:
- 生物技术和基因工程 生物技术和基因工程
- 医学诊断 医学诊断 医学诊断
- 生物信息学是一种生物信息学.
背景情况:
- 克里斯普尔 (集群定期间隔的简短的帕林德罗姆重复) 技术已经成为精确基因编辑的强大工具.
- 它在疾病检测中的应用近年来迅速发展,需要对研究领域的全面概述.
- 了解历史发展和当前趋势对于未来的进步至关重要.
研究的目的:
- 进行与疾病检测相关的CRISPR研究的文献分析.
- 确定该领域的关键趋势,有影响力的作者,机构和国家.
- 绘制基于CRISPR的疾病检测的智力结构和引用格局.
主要方法:
- 在Scopus数据库中对1992年至2023年期间的出版物进行了全面的搜索.
- 在使用VOSviewer,RStudio和MS Excel对1407篇选文章进行了圣经计量分析.
- 数据分析包括年度出版趋势,引用模式,作者归属以及关键词的共同出现.
主要成果:
- 在2018年至2023年期间,CRISPR研究在开始缓慢后出现了显著的激增.
- 德国,美国,中国,印度和英国是CRISPR疾病检测研究中的领先国家.
- 作者Liu,C.和Li,Y.显示了大量的出版物,而Broughton在2020年对SARS-CoV-2检测的研究得到了高度引用.
结论:
- 图书统计分析强调了CRISPR在疾病检测中的指数级增长和日益增长的全球影响.
- 已经确定了关键的研究中心和有影响力的贡献者,为该领域提供了路线图.
- 这项研究为研究人员,政策制定者和利益相关者提供了有价值的见解,以指导未来在基于CRISPR的诊断方面的努力.
相关概念视频
02:53CRISPR and crRNAs
16.9K
Bacteria and archaea are susceptible to viral infections just like eukaryotes; therefore, they have developed a unique adaptive immune system to protect themselves. Clustered regularly interspaced short palindromic repeats and CRISPR-associated proteins (CRISPR-Cas) are present in more than 45% of known bacteria and 90% of known archaea.
The CRISPR-Cas system stores a copy of foreign DNA in the host genome and uses it to identify the foreign DNA upon reinfection. CRISPR-Cas has three different...
The CRISPR-Cas system stores a copy of foreign DNA in the host genome and uses it to identify the foreign DNA upon reinfection. CRISPR-Cas has three different...
16.9K
01:59CRISPR
50.3K
Genome editing technologies allow scientists to modify an organism’s DNA via the addition, removal, or rearrangement of genetic material at specific genomic locations. These types of techniques could potentially be used to cure genetic disorders such as hemophilia and sickle cell anemia. One popular and widely used DNA-editing research tool that could lead to safe and effective cures for genetic disorders is the CRISPR-Cas9 system. CRISPR-Cas9 stands for Clustered Regularly Interspaced...
50.3K
02:31Homologous Recombination
50.4K
The basic reaction of homologous recombination (HR) involves two chromatids that contain DNA sequences sharing a significant stretch of identity. One of these sequences uses a strand from another as a template to synthesize DNA in an enzyme-catalyzed reaction. The final product is a novel amalgamation of the two substrates. To ensure an accurate recombination of sequences, HR is restricted to the S and G2 phases of the cell cycle. At these stages, the DNA has been replicated already and the...
50.4K
01:05Single Nucleotide Polymorphisms-SNPs
14.9K
A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
14.9K