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Wenbin Ouyang¹, Bei Tang¹, Yongmei He²

¹Department of Epidemiology, Hunan Normal University School of Medicine, Changsha, China.

Frontiers in microbiology

|July 26, 2024

概括

定期体育活动可以降低心血管疾病 (CVD) 的预测因素 - - 状腺斑块 (CP) 的风险. 这种益处是由肠道微生物群介导的,特别是增加了Clostridiales的丰富性.

科学领域:

心血管健康心血管健康
微生物组研究微生物组研究
预防医学预防医学

背景情况:

冠状动脉斑块 (CP) 是心血管疾病 (CVD) 的重要预测因素.
众所周知,身体活动会影响CP并改变肠道微生物群的组成.
肠道微生物群在体力活动-CP关系中的调解作用仍然不清楚.

研究的目的:

为了调查身体活动和动脉斑块 (CP) 之间的联系.
探索肠道微生物群在调解身体活动对CP的影响中的作用.

主要方法:

进行了一项病例控制研究,对30名CP患者和31名对照进行了研究.
后勤回归分析了身体活动-CP关联.
使用LefSe和PhyloMed来评估肠道微生物群和调解效应.

主要成果:

充足的体力活动与CP风险降低有显著的关联 (ORadj:0.25).
CP与增加的Bacteroidales有关,而Clostridiales在对照中占主导地位.
身体活动与更高的Clostridiales和较低的Bacteroidetes丰度相关.
肠道微生物群显著调解了身体活动与CP的关联 (p=0.03).

结论:

充足的体力活动与心血管斑块的风险降低有关.
身体活动的心脏保护作用是由肠道微生物群介导的,特别是通过增加Clostridiales的丰富性.

关键词:

冠状动脉斑块冠状动脉斑块是什么我们的肠道微生物群.调解调解是一种调解方式.遗传学树是一种遗传学树.身体活动身体活动

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