一种高脂肪饮食诱导了类似抑郁症的表型,通过白蛋白-HCRTR1介导的炎症激活
Jingyi Dong1, Jinghui Zhang1, Shangping Cheng1
1School of Life Sciences, Zhejiang Chinese Medical University, Hangzhou, 310053, China. lujing2016@zju.edu.cn.
Food & function
|July 26, 2024
概括
高脂肪饮食 (HFD) 通过改变肠道细菌并增加肝素-1水平,可以引发焦虑和抑郁. 用SB334867治疗逆转了这些负面影响,这表明了与饮食有关的情绪障碍的潜在治疗标.
科学领域:
- 神经科学是一个神经科学.
- 代谢障碍 代谢障碍 代谢障碍
- 肠道微生物组研究研究
背景情况:
- 在全球范围内,高脂肪饮食 (HFD) 与心理健康障碍风险增加有关.
- 高晶体管破坏肠道微生物群-大脑轴,导致心理健康问题.
- 与食欲相关的Hypocretin-1在HFD环境中显示出与抑郁症的潜在但未经证实的联系.
研究的目的:
- 为了研究HFD,高克列-1水平和情绪功能障碍之间的关系.
- 探索HFD对肠道微生物群,大脑炎症和脂质积累的影响.
- 评估白素受体1抗剂 (SB334867) 在HFD诱导的行为变化中的治疗潜力.
主要方法:
- 成年雄性大鼠被食HFD或正常饮食八周.
- 评估了行为测试,血生物化学分析和海马炎症标志物.
- 研究了肠道微生物组的转基因组学/代谢学,3T3-L1细胞脂质积累和BV2细胞激活.
主要成果:
- HFD诱发了类似焦虑和类似抑郁的行为,增加了血脂质,并提高了海波克莱-1和-2水平.
- HFD改变了肠道微生物群的组成,增加了炎症因素,并导致海马微质激活与脂质沉积.
- SB334867治疗逆转了HFD诱导的体重增加,情绪缺陷和神经炎症,同时改善了血脂质谱.
结论:
- HFDs可能会诱导情绪功能障碍,可能由增加的低白-1和脂质积累介导.
- SB334867在减轻HFD相关的负面行为和生理影响方面表现出有效性.
- 克列-1信号传递代表了管理HFD相关情绪障碍的潜在治疗标.
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