在平行进化中的替代拼接和鱼的进化潜力
1Ministry of Education Key Laboratory for Biodiversity Science and Ecological Engineering, Institute of Biodiversity Science, Center for Evolutionary Biology, School of Life Sciences, Fudan University, Shanghai, China.
The Journal of animal ecology
|July 26, 2024
概括
自然选择推动了可预测的适应. 这项研究表明,与基因表达相比,替代拼接,一种转录后过程,在平行适应中起着独特的作用,为进化潜力提供了洞察力.
科学领域:
- 进化生物学 进化生物学
- 基因组学就是基因组学.
- 分子生物学分子生物学
背景情况:
- 自然选择的可预测性是通过对类似环境的重复适应来研究的.
- 适应中的基因表达差异得到了很好的研究,但在平行适应中,像替代拼接一样,对转录后调节的理解较少.
研究的目的:
- 评估替代拼接在平行适应中的作用.
- 为了比较并行表达和拼接基因的遗传结构和生物过程.
- 评估基因表达与替代拼接的进化潜力.
主要方法:
- 重新分析了三种脊椎鱼 (Gasterosteus aculeatus) 生态型的转录组数据.
- 在海洋和淡水生态型对中识别具有重复表达或拼接分歧的基因.
- 基因架构,生物过程和平行表达和拼接基因之间的核酸多样性的比较.
主要成果:
- 不同的拼接和表达都显示了平行分歧,拼接显示的平行度低于表达.
- 平行拼接和表达差异涉及不同的遗传变异和基因组.
- 平行拼接的基因比平行表达的基因具有更高的核酸多样性,这表明拼接不太容易受到侵蚀.
结论:
- 替代拼接对并行适应有独特的贡献.
- 拼接变异在面临环境变化的野生种群的进化潜力中起着重要作用.
- 了解拼接对于预测进化对环境变化的反应至关重要.
相关概念视频
Exon Recombination
3.6K
The evolution of new genes is critical for speciation. Exon recombination, also known as exon shuffling or domain shuffling, is an important means of new gene formation. It is observed across vertebrates, invertebrates, and in some plants such as potatoes and sunflowers. During exon recombination, exons from the same or different genes recombine and produce new exon-intron combinations, which might evolve into new genes.
Exon shuffling follows “splice frame rules.” Each exon...
Exon shuffling follows “splice frame rules.” Each exon...
3.6K
Convergent Evolution
27.7K
Evolution shapes the features of organisms over time, ensuring that they are suited for the environments in which they live. Sometimes, selection pressure leads to the rise of similar but unrelated adaptations in organisms with no recent common ancestors, a process known as convergent evolution.
27.7K
Gene Duplication and Divergence
6.1K
The seminal work of Ohno in 1970 popularized the idea of gene duplication and divergence. DNA sequence comparison studies reveal that a large portion of the genes in bacteria, archaebacteria, and eukaryotes was generated by gene duplication and divergence, indicating its critical role in evolution.
The duplicated copies of the gene are called Paralogs. Paralogs with similar sequences and functions form a gene family. Across several species, a large number of gene families are...
The duplicated copies of the gene are called Paralogs. Paralogs with similar sequences and functions form a gene family. Across several species, a large number of gene families are...
6.1K
Alternative RNA Splicing
21.1K
Alternative RNA splicing is the regulated splicing of exons and introns to produce different mature mRNAs from a single pre-mRNA. Unlike in constitutive splicing where a single gene produces a single type of mRNA, alternative splicing allows an organism to produce multiple proteins from a single gene and plays an important role in protein diversity.
There are five types of alternative RNA splicing that vary in the ways the pre-mRNA segments are removed or retained in the mature mRNA. The first...
There are five types of alternative RNA splicing that vary in the ways the pre-mRNA segments are removed or retained in the mature mRNA. The first...
21.1K
Gene Flow
35.0K
Gene flow is the transfer of genes among populations, resulting from either the dispersal of gametes or from the migration of individuals.
35.0K
Gene Evolution - Fast or Slow?
7.1K
The genomes of eukaryotes are punctuated by long stretches of sequence which do not code for proteins or RNAs. Although some of these regions do contain crucial regulatory sequences, the vast majority of this DNA serves no known function. Typically, these regions of the genome are the ones in which the fastest change, in evolutionary terms, is observed, because there is typically little to no selection pressure acting on these regions to preserve their sequences.
In contrast, regions which code...
In contrast, regions which code...
7.1K


