在先进的皮肤状细胞癌中使用Cemiplimab的现实世界经验
Scott Strum1,2, Seth Climans1,2, Victoria Purcell3
1Department of Oncology, Division of Medical Oncology, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada.
Journal of cutaneous medicine and surgery
|July 26, 2024
概括
塞米普利马布在加拿大现实环境中对晚期皮肤状细胞癌 (cSCC) 显示了可容忍的毒性和有效性. 这项研究提供了关于耐火局部晚期和转移性cSCC患者治疗结果的关键数据.
科学领域:
- 在瘤学瘤学.
- 皮肤病学 皮肤病学
- 免疫治疗是一种免疫疗法.
背景情况:
- 皮肤状细胞癌 (cSCC) 是加拿大流行的一种非黑色素瘤皮肤癌.
- 有限的现实世界数据存在于对耐火局部先进 (LA) 和转移性cSCC的CEMIPLIMAB治疗.
研究的目的:
- 评估在加拿大现实环境中使用塞米普利马布治疗的晚期cSCC患者的人口和临床结果.
- 评估塞米普利马布对耐火性LA和转移性cSCC的安全性和有效性.
主要方法:
- 对成年患有耐火性LA和转移性cSCC的CEMIPLIMAB治疗患者的回顾性分析.
- 收集了有关患者人口统计,治疗特征,无进展生存 (PFS) 和整体生存 (OS) 的数据.
主要成果:
- 分析了40名患者;16名 (40%) 有LA,24名 (60%) 有转移性疾病.
- 中位数PFS为11.5个月 (95%CI 7.0-NR),中位数OS没有达到 (95%CI 9.1个月-NR).
- 塞米普利马布的不良反应发生在25%的患者中,具有一般可容忍的毒性.
结论:
- 塞米普利马布在现实环境中证明了耐火性LA和转移性cSCC的安全性和有效性.
- 虽然12个月的OS和PFS估计低于关键试验,但毒性是可以管理的.
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