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在耐火性胃衰竭中,胃口内膜内镜性脊髓动脉切除术后,是否可以预测腹腔双阴膜测量参数的临床反应?
K W E Sweerts1, Z Mujagic1, J W A Straathof2
1Department of Gastroenterology and Hepatology, Maastricht University Medical Center, Maastricht, the Netherlands.
在经过胃口口腔内镜性脊髓瘤切除术 (G-POEM) 的耐火性胃衰竭 (GP) 患者中,双阴管内镜测量 (ADM) 不能预测治疗反应. 需要进一步的研究来确定G-POEM在GP中的成功可靠预测因素.
科学领域:
- 胃肠病学 胃肠病学
- 内镜手术是一种内镜手术.
- 诊断力测仪的诊断力测仪
背景情况:
- 胃外口内镜性胆髓瘤切除术 (G-POEM) 在耐火性胃衰竭 (GP) 方面表现有前途.
- 对G-POEM患者的选择需要客观的参数,而腹十二指管测量 (ADM) 是一个潜在的工具.
- 最有可能受益于G-POEM的患者的特征仍然不清楚.
研究的目的:
- 为了确定预测耐火性胃衰竭 (GP) 中对G-POEM的治疗反应的双阴肠胃测量 (ADM) 参数.
- 评估ADM在选择适合G-POEM候选人的实用性.
主要方法:
- 对接受G-POEM (2017-2022) 的不耐药GP患者的回顾性分析.
- 评估ADM参数,包括部低移动性,胆囊和神经病变性肠道模式.
- 治疗反应定义为G-POEM后12个月GCSI得分下降≥1点;用于预测分析的逻辑回归.
主要成果:
- 包括60名耐火性GP患者;52人有可用的响应数据.
- 异常的ADM发现普遍存在 (77%),58%的肠道动力障碍模式存在,但腹腔动力低下 (33%) 和胆囊 (12%) 较少.
- 在12个月的随访期间,在响应者和不响应者之间没有观察到基线ADM参数的显著差异.
结论:
- 在耐火性胃衰竭 (GP) 患者中,双胞胎肠胃测量 (ADM) 参数无法预测G-POEM的临床反应.
- 发现了异常ADM的高患病率,特别是肠道动力障碍.
- 目前的ADM参数不足以指导G-POEM患者在不耐药GP中的选择.
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