富含血小板血和富含生长因子的血在口外伤口护理中
Jeniffer Perussolo1, Elena Calciolari1,2, Xanthippi Dereka3
1Centre for Oral Clinical Research, Institute of Dentistry, Faculty of Medicine and Dentistry, Queen Mary University of London, London, UK.
Periodontology 2000
|July 26, 2024
概括
富含血小板血 (PRP) 和富含生长因子 (PRGFs) 的血对治疗糖尿病足和烧伤等口外伤很有前途. 这些再生疗法可能会加速愈合和减少伤口大小,但需要逐案考虑.
科学领域:
- 再生医学是一种再生医学.
- 伤口愈合 治愈 伤口愈合
- 生物材料是一种生物材料.
背景情况:
- 非口腔伤口护理带来了重大挑战,影响了患者的生活质量.
- 正在探索自身血小板缩剂,如富含血小板血 (PRP) 和富含生长因子 (PRGFs) 的血,用于伤口愈合.
- 现有的关于PRP和PRGF在各种口外伤类型中的疗效的文献是广泛的,但需要综合.
研究的目的:
- 审查和评估PRP和PRGF在外口腔伤口护理中的临床疗效和安全性.
- 评估这些疗法对生活质量,疼痛,成本和复发率的影响.
- 确定有关PRGF和以患者为中心的结果的文献上的差距.
主要方法:
- 现有文献的叙述性审查.
- 专注于常见的非口腔伤口类型:糖尿病足,静脉腿,压力,手术伤口和烧伤.
- 评估报告临床结果,安全性,患者感知,成本和复发情况的研究.
主要成果:
- 据报道,PRP具有较低的副作用风险,并在各种医学专业领域表现出有效性.
- PRGF表现出有希望的结果,尽管与PRP相比,文献不那么广泛.
- 研究表明,在使用这两种疗法时,有可能减少伤口大小和加快愈合时间.
- 关于患者感知,成本效益,复发和并发症的数据仍然是可变的.
结论:
- PRP和PRGF显示出作为各种口外伤口和的辅助或替代疗法的潜力.
- 这些再生疗法可以减少伤口大小和更快的愈合.
- 治疗决策应根据伤口类型,严重程度和患者因素进行个性化.
相关概念视频
Phases of Wound Repair
5.9K
Following injury, the integrity of the injured tissues must be reestablished. For example, in skin tissue, wound repair involves coordination among resident skin cells, blood mononuclear cells, extracellular matrix, growth factors, and cytokines to complete the healing cascade.
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...
5.9K
Formation of the Platelet Plug
5.6K
The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
5.6K
Clinical Applications of Epidermal Stem Cells
2.7K
Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
2.7K
Inflammatory Response II: Inflammatory Exudate and Tissue Repair
4.8K
The immune system's inflammatory response destroys the invading pathogen, permitting the tissue to heal. The changes during the cellular and vascular stages allow exudate formation at the site of inflammation. The inflammatory exudate released from the wound has high protein content and a specific gravity above 1.020.
The typical wound exudate is odorless, transparent, straw-colored, thin, and watery. Exudate, however, can differ depending on the state of wound healing. Likewise, the...
The typical wound exudate is odorless, transparent, straw-colored, thin, and watery. Exudate, however, can differ depending on the state of wound healing. Likewise, the...
4.8K
Clot Retraction and Fibrinolysis
5.3K
After a fibrin clot is formed, the next step is clot retraction, a vital process facilitated by platelet contractile proteins, such as actin and myosin. These proteins pull the fibrin strands closer together and condense the clot. This action reduces the size of the clot, creating a smaller, denser structure that effectively seals off the damaged vessel. Clot retraction consolidates the clot and helps with wound healing by bringing the edges of the damaged blood vessel closer together.
5.3K
Introduction to Hemostasis
7.0K
Hemostasis is a complex physiological process that prevents excessive bleeding when a blood vessel is injured. It's crucial for maintaining the integrity of the circulatory system, as it ensures that our blood remains fluid while still within the vascular network and yet clots to prevent blood loss upon vessel injury.
The three phases of hemostasis involve many clotting factors present in plasma and several substances released by platelets and injured tissue cells. It is a fast, localized,...
The three phases of hemostasis involve many clotting factors present in plasma and several substances released by platelets and injured tissue cells. It is a fast, localized,...
7.0K


