中等高度作为孤立先天性形的风险因素. 来自病例控制多中心多区域研究的结果
Blanca Rebeca Ibarra-Ibarra1, Leonora Luna-Muñoz2, Osvaldo M Mutchinick2
1Laboratory of Translational Medicine, UNAM-INC Unit, Instituto Nacional de Cardiología, Ignacio Chávez, Mexico City, Mexico.
Birth defects research
|July 26, 2024
概括
中等高度与某些先天缺陷有关,作为水头症和小症等疾病的风险因素,同时提供对其他疾病的保护,如脊柱裂. 这表明与高度相关的梯度对先天性形的影响.
科学领域:
- 环境流行病学环境流行病学
- 甲状腺学 甲状腺学是一门学科.
- 公共卫生 公共卫生
背景情况:
- 高海拔生活与某些出生缺陷的患病率增加有关.
- 中等高度 (1500-2500米) 与先天性心脏病和低出生体重有关.
- 有限的研究存在于其他孤立的先天性形在中等高度.
研究的目的:
- 为了确定在低至中等海拔地区出生时孤立的先天性形的患病率.
- 评估中等高度是否构成与高海拔相似的孤立先天性缺陷的风险因素.
- 调整高度和形风险分析中的混因素.
主要方法:
- 一个多中心,多区域的病例控制研究,涉及13个孤立的先天性形.
- 从墨西哥登记处 (1978-2019) 分析低 (10-1433米) 和中等 (1511-2426米) 高度的活产.
- 使用后勤回归模型来估计患病率和风险,并根据母亲的年龄,性别平等,社会经济地位和糖尿病进行调整.
主要成果:
- 在中等海拔地区,水头症和微小症的患病率更高.
- 在中等海拔地区,脊柱裂,耳前标记和胃病的患病率较低.
- 中等高度被确定为水头,小,裂唇和多巴的危险因素,并为脊柱裂变提供保护.
结论:
- 适度的海拔,像高海拔一样,与特定的孤立先天性形的风险增加或保护作用有关.
- 这些发现表明,高度梯度对先天性形的发生有潜在的影响.
- 在中等高度的环境因素可能会影响先天性异常的发展.
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