一个可扩展,可编程的神经刺激器,用于增强神经接口应用程序中的通用性.
Meng Yin1,2, Xiao Wang1,2, Liuxindai Zhang1,2
1State Key Laboratory of Digital Medical Engineering, School of Biomedical Engineering, Hainan University, Haikou 570228, China.
Biosensors
|July 26, 2024
概括
这项研究在芯片上引入了一个可扩展的32通道神经刺激器,用于精确的神经接口刺激. 它的灵活设计提供了广泛的电流范围和高分辨率,增强了刺激策略.
科学领域:
- 生物医学工程 生物医学工程
- 神经科学是一个神经科学.
- 电气工程 电气工程
背景情况:
- 有效的神经刺激需要量身定制的参数,但当前的系统在平衡电流,分辨率和通道数量方面面临挑战,限制了概括性.
- 现有的神经刺激器往往难以提供适合各种神经接口应用的广泛刺激参数.
研究的目的:
- 开发一个高度可扩展和可编程的神经刺激器System-on-Chip (SOC),拥有32个独立通道.
- 通过提供灵活和精细的刺激策略,增强神经刺激器在各种神经接口的普遍性.
主要方法:
- 设计了一个系统芯片 (SOC) 神经刺激器,具有32个独立的刺激通道和高达±22.5V的合规电压.
- 集成的8位电流模式DAC具有用户可选择的双范围,适用于低电流微刺激 (4.31μA/bit) 和高电流应用 (48.00μA/bit).
- 实施了一种专门的通信协议,用于可编程控制刺激波形.
主要成果:
- 实现了12.24mA的广泛刺激电流范围,具有用于生物刺激的高分辨率.
- 证明了对刺激波形的完全可编程控制,扩大了可实现的刺激参数范围.
- 通过体内电生理学实验成功验证了神经刺激器的功能.
结论:
- 拟议的32通道神经刺激器SOC为各种神经接口提供了灵活和可扩展的架构.
- 这种先进的刺激器可以实现更精细和多样化的刺激策略,提高应用程序的有效性.
- 该系统的设计解决了当前神经刺激器的局限性,为神经工程更广泛采用铺平了道路.
相关概念视频
Long-term Potentiation
Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Long-term Potentiation
Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Hebbian LTP
LTP can occur when presynaptic neurons...
Hebbian LTP
LTP can occur when presynaptic neurons...
Integration of Synaptic Events
Synaptic integration mainly includes the summation of graded potentials. Graded potentials, regardless of their type, cause subtle alterations in membrane voltage, resulting in either depolarization or hyperpolarization. These incremental changes, when combined or summed, can propel the neuron toward its threshold. Consider, for example, a membrane experiencing a +15 mV shift, causing it to depolarize from -70 mV to -55 mV. In this scenario, graded potentials govern the membrane's ability to...
Neuronal Communication
Neurons, the fundamental units of the brain and nervous system, communicate through complex electrochemical signals that underpin all cognitive and bodily functions. This communication is primarily facilitated by a process involving the generation and propagation of an action potential along the axon of the neuron. When the internal electrical charge of a neuron surpasses a certain threshold, an action potential is triggered. This rapid change in voltage travels swiftly along the axon to the...


