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鉴定肌肉纤维大小的基因组预测器

João Paulo L F Guilherme¹, Ekaterina A Semenova^2,3, Naoki Kikuchi⁴

¹Human Genome and Stem Cell Research Center, University of São Paulo, São Paulo 05508-090, SP, Brazil.

|July 26, 2024

概括

研究人员确定了57种与肌肉量和肌肉纤维大小相关的遗传变异. 这些遗传变异可能会使个人倾向于电力运动,影响肌肉力量和运动表现.

科学领域:

遗传学和人类生理学
骨肌肉生物学骨肌肉生物学
运动科学运动科学运动科学

背景情况:

肌肉纤维横截面积 (CSA) 与骨肌肉质量和强度相关,而缩是萨尔科佩尼亚的关键.
肌肉纤维大小是一个受遗传学和环境影响的多基因特征,但基础遗传变异的理解很差.
识别影响肌肉纤维大小的遗传因素对于理解个人之间的力量和运动潜力的差异至关重要.

研究的目的:

调查以前与尾肌肉量和快速缩纤维肌肉纤维大小相关的遗传变异之间的关联.
确定已识别的遗传变异是否与各种队列的肌肉强度指标和运动表现相关.

主要方法:

一项全基因组关联研究 (GWAS) 分析了148名身体活跃个体中的1535个遗传变异.
确定了57个与肌肉纤维大小相关的单核酸多态 (SNP) (p < 0.05).
进一步验证涉及英国生物银行 (n=359,729) 的手握强度和运动员队列 (n=1246) 的运动员地位和举重表现.

主要成果:

57个SNP显示与快肌肉纤维CSA有显著的关联.
在这些中,31个SNP也与英国大型生物库队列中的手握强度有关.
16个SNP与运动员的状态 (短跑者,摔者,力量,速度力量) 以及体育和非体育队伍的举重表现有关.

结论:

57种基因变异与尾肌瘦质量和快肌肉纤维大小有关.
这些变体表现出一致的方向性,肌肉质量增加的等位基因与肌肉纤维大小,强度和力量运动员状态正相关.
鉴定到的基因变异可能部分解释了对强度运动的倾向以及肌肉质量和力量的差异.

关键词:

运动员运动员运动员运动员的体育状态遗传多样性遗传多样性遗传倾向遗传倾向遗传倾向基因型基因型基因型人类遗传学人类遗传学肌肉缩过高的情况肌肉的力量肌肉的力量肌肉的力量肌纤维纤维是一种纤维.运动运动运动运动运动运动运动.

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