MAFLD 流行:药物治疗方法发展的最新情况
Farah Khaznadar1,2, Omar Khaznadar3, Ana Petrovic1
1Faculty of Dental Medicine and Health Osijek, Josip Juraj Strossmayer University of Osijek, 31000 Osijek, Croatia.
Current issues in molecular biology
|July 26, 2024
概括
与代谢相关的脂肪肝疾病 (MAFLD) 影响全球10亿人. 最近的药物开发提供了希望,对MAFLD和代谢功能障碍相关的脂肪肝炎 (MASH) 的新疗法即将获得批准.
科学领域:
- 肝病学和胃肠道学
- 药理学和药物开发领域
- 代谢疾病 代谢疾病
背景情况:
- 代谢相关的脂肪肝疾病 (MAFLD) 是一种全球流行病,影响全球约10亿人.
- MAFLD是一种与肥胖和2型糖尿病等代谢障碍相关的渐进性肝病,可能导致肝硬化和肝癌 (HCC).
- 目前,对MAFLD的药理选择有限,因此需要多学科的治疗方法.
研究的目的:
- 审查对MAFLD药物开发的最新进展.
- 要突出最接近监管批准的治疗MAFLD和代谢功能障碍相关的脂肪肝炎 (MASH) 的分子.
- 强调迫切需要针对肝脏脂肪,纤维化和炎症的有效疗法.
主要方法:
- 对MAFLD治疗的最新临床试验和监管批准的文献综述.
- 对候选药物的分析,重点关注它们在改善肝脏组织学方面的有效性.
- 检查MAFLD复杂的病因和肝外影响,以告知治疗策略.
主要成果:
- 萨罗格利塔扎尔 (Lipaglyn®) 在2020年在印度被批准用于MASH.
- 雷兹迪夫拉 (RezdiffraTM) 在美国获得了针对成人MASH的加速批准.
- 许多分子正在临床试验的后期阶段,表明MAFLD药物治疗的有希望的管道.
结论:
- 随着最近的药物批准,MAFLD治疗的景观正在迅速发展.
- 密集的研究和临床试验预计将在不久的将来产生几种新的批准疗法.
- 开发能够治疗肥胖症,纤维化和炎症的药物是成功治疗MAFLD和获得监管授权的关键.
相关概念视频
Drug Administration and Therapy Phases: Overview
429
Drugs, the chemical agents used in diagnosing, treating, or preventing diseases, undergo a four-phase process of development: pharmaceutic, pharmacokinetics, pharmacodynamics, and therapeutic.
The pharmaceutical phase focuses on leveraging the physicochemical properties of the drug to design and manufacture an effective product. Variants include orally administered tablets or capsules, topical creams or ointments, and parenteral-delivery solutions or emulsions.
The pharmacokinetic phase...
The pharmaceutical phase focuses on leveraging the physicochemical properties of the drug to design and manufacture an effective product. Variants include orally administered tablets or capsules, topical creams or ointments, and parenteral-delivery solutions or emulsions.
The pharmacokinetic phase...
429
Drug Therapy
41
The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
Antianxiety Medications
41
Inflammatory Bowel Disease IV: Pharmacological Management
124
Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
Pharmacologic...
124
Antidepressant Drugs: MAOIs and Other Agents
209
Atypical antidepressants, including bupropion (Wellbutrin), mirtazapine (Remeron), nefazodone (Serzone), trazodone (Desyrel), and vilazodone (Viibryd), offer unique mechanisms of action. Bupropion weakly inhibits dopamine and norepinephrine reuptake, aiding depression treatment and smoking cessation, with a low risk of sexual dysfunction. Mirtazapine enhances serotonin and norepinephrine neurotransmission, leading to sedation, increased appetite, and weight gain. As a result, it helps treat...
209
Drug Discovery: Overview
7.7K
Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...
7.7K
Pharmacovigilance
810
Post-marketing surveillance is a critical component of pharmaceutical regulation, often uncovering unanticipated adverse drug reactions (ADRs) once a drug is widely used over an extended period.
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
810


