感染COVID-19的过敏性鼻炎患者的潜在保护因素
Jiaoyue Dong1,2, Dingyuan Su1,2, Binbin Zhao1,2
1Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Henan University, Kaifeng 475004, China.
Current issues in molecular biology
|July 26, 2024
概括
过敏性鼻炎 (AR) 和类似的呼吸道过敏性疾病可以提供对COVID-19感染的保护. 研究表明,包括ACE2受体表达在内的潜在分子机制,有助于这种保护作用.
科学领域:
- 免疫学 免疫学 免疫学
- 病毒学 病毒学
- 呼吸系统医学 呼吸系统医学
背景情况:
- 在COVID-19大流行初期,呼吸道过敏疾病如喘和过敏性鼻炎 (AR) 被怀疑是危险因素.
- 新出现的证据表明,这些条件可能有助于预防COVID-19感染,这与最初的假设相反.
研究的目的:
- 审查有关COVID-19和过敏性鼻炎 (AR) 之间的关系的现有证据.
- 在过敏性鼻炎患者中阐明COVID-19感染的潜在分子机制.
- 为COVID-19预防和治疗策略提供新的见解.
主要方法:
- 关于COVID-19和过敏性鼻炎现有研究的文献综述.
- 分子机制的分析,包括ACE2受体表达和细胞因子网络.
- 考虑影响因素,如类固醇激素和年龄.
主要成果:
- 气道过敏性疾病,特别是过敏性鼻炎,可能不是严重COVID-19的危险因素.
- 有证据表明过敏性鼻炎对抗COVID-19感染的潜在保护作用.
- 低水平的ACE2受体表达和特定的细胞因子概况与保护机制有关.
结论:
- 过敏性鼻炎及其相关的分子通路似乎对抗COVID-19感染具有保护作用.
- 了解这些机制可以为COVID-19的新治疗和预防方法提供信息.
- 需要进一步的研究,以充分探索过敏性疾病在病毒感染中的影响.
更多相关视频
相关概念视频
Transmission-based Precautions II: Airborne and Protective Environment
1.2K
Transmission-based precautions are for patients infected or suspected to be infected (or colonized) with organisms posing a significant risk to others. The transmission precautions include airborne and protective environment precautions.
Airborne precautions:
Use airborne precautions when treating patients known or suspected to have diseases that spread through the air—for example, tuberculosis or measles. These organisms are present in smaller droplets expelled by an infected person and...
Airborne precautions:
Use airborne precautions when treating patients known or suspected to have diseases that spread through the air—for example, tuberculosis or measles. These organisms are present in smaller droplets expelled by an infected person and...
1.2K
Factors Affecting the Risk of Infection
11.5K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
11.5K
Allergic Reactions
27.3K
Overview
27.3K
Standard Precaution
1.9K
Standard precautions are the minimum infection control safeguards used while caring for all patients, irrespective of their disease condition. They help prevent the spread of common infectious microorganisms to healthcare workers, patients, and visitors in all healthcare settings.
Hand hygiene is the most crucial means to prevent the transmission of disease. Employers are legally required to provide their workers with personal protective equipment (PPE) to minimize exposure or contact with...
Hand hygiene is the most crucial means to prevent the transmission of disease. Employers are legally required to provide their workers with personal protective equipment (PPE) to minimize exposure or contact with...
1.9K
Transmission-based Precautions I: Contact, Enteric, and Droplets
3.5K
Transmission-based precautions are for patients known to be infected or suspected to be infected or colonized with organisms that pose a significant risk to others. Some transmission-based precautions include contact, enteric, and droplet.
Contact Precautions:
Contact precautions are the measures taken to prevent the transmission of infectious agents, especially epidemiologically important microorganisms such as MRSA or influenza, primarily transmitted through direct or indirect contact with an...
Contact Precautions:
Contact precautions are the measures taken to prevent the transmission of infectious agents, especially epidemiologically important microorganisms such as MRSA or influenza, primarily transmitted through direct or indirect contact with an...
3.5K
Asthma-I: Introduction
2.6K
Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
2.6K


